The role of mesenchymal stem cell transplantation for ischemic stroke and recent research developments

作者全名："Zhou, Li; Wang, Jiani; Huang, Jiagui; Song, Xiaosong; Wu, Youlin; Chen, Xia; Tan, Yongjun; Yang, Qin"

作者地址："[Zhou, Li; Wang, Jiani; Huang, Jiagui; Song, Xiaosong; Wu, Youlin; Chen, Xia; Tan, Yongjun; Yang, Qin] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China"

通信作者："Yang, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000891527100001

JCR分区：Q2

影响因子：3.4

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：mesenchymal stem cells (MeSH ID; D059630); stem cell transplantation (HSCT); ischemic stroke (IS); stem-cell based therapy; experimental treatment

摘要："Ischemic stroke is a common cerebrovascular disease that seriously affects human health. However, most patients do not practice self-care and cannot rely on the current clinical treatment for guaranteed functional recovery. Stem cell transplantation is an emerging treatment studied in various central nervous system diseases. More importantly, animal studies show that transplantation of mesenchymal stem cells (MSCs) can alleviate neurological deficits and bring hope to patients suffering from ischemic stroke. This paper reviews the biological characteristics of MSCs and discusses the mechanism and progression of MSC transplantation to provide new therapeutic directions for ischemic stroke."

基金机构：National Natural Science Foundation of China; [82171456]; [81971229]

基金资助正文："Funding This study was supported by the National Natural Science Foundation of China (Grant No. 82171456 and 81971229, to QY)."