Investigating potential ferroptosis-related differentially expressed genes of UVB-induced skin photodamage

作者全名："Deng, Li; Li, Yi; Wu, Qian; Zeng, QianWen; He, Yuanmin; Chen, AiJun"

作者地址："[Deng, Li; Wu, Qian; Zeng, QianWen; Chen, AiJun] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China; [Deng, Li; He, Yuanmin] Southwest Med Univ, Affiliated Hosp, Dept Dermatol, Luzhou, Peoples R China; [Li, Yi] Southwest Med Univ, Affiliated Hosp, Dept Nucl Med, Luzhou, Peoples R China; [Wu, Qian] Chongqing Med Univ, Qijiang Hosp, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China; [Chen, AiJun] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China"

通信作者："Chen, AJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF DERMATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000892145200001

JCR分区：Q2

影响因子：3.6

年份：2023

卷号：62

期号：1

开始页：79

结束页：87

文献类型：Article

关键词：　

摘要："Objectives: Ultraviolet B (UVB) is one of the most dangerous insults for skin, which can cause skin sunburn, pigment disease, photoaging, and photocarcinogenesis. This study aimed to identify pathogenic genes related to ferroptosis in the skin of humans after UVB radiation. Methods: The gene expression profiles (GSE41078, GSE54413) were downloaded from the Gene Expression Omnibus (GEO) database, and the ferroptosis-related genes (FRGs) were downloaded from the Genecards database. To identify the differentially expressed genes (DEGs) and obtain differentially expressed FRGs by intersecting DEGs with FRGs. To identify the functional annotation and potential pathways by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Differentially expressed FRGs-associated protein-protein interaction network (PPI) was performed by STRING database and Cytoscape software. Results: A total of 628 co-expressed DEGs of the two profiles (GSE41078 and GSE54413) were identified, including 371 upregulated and 257 downregulated DEGs. A total of 32 differentially expressed FRGs were identified. The results of GO analyses showed that, in the biological processes, UVB had a great influence on the response to oxidative stress; in the molecular functions, UVB had a great influence on antioxidant activity; in the cellular components, UVB had a great influence on endocytic vesicle lumen. The key pathways of differentially expressed FRGs were identified by KEGG analyses. The most significant 12 central node genes were identified by PPI network. Conclusion: We identified differentially expressed FRGs candidate genes and pathways in UVB-induced skin photodamage, which could contribute to the development of new therapeutic targets for skin photodamage."

基金机构：General project of Chongqing Science and Technology Commission [cstc2021jcyj-msxm0138]

基金资助正文："General project of Chongqing Science and Technology Commission, cstc2021jcyj-msxm0138."