Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14 731 Patients Diagnosed with Invasive Breast Cancer

作者全名："Sun, Jiazheng; Tan, Jinxiang; Zheng, Hong; Jiang, Jun; Zou, Tianning; Li, Hongyuan; Ren, Guosheng; Yang, Dejuan"

作者地址："[Sun, Jiazheng; Tan, Jinxiang; Li, Hongyuan; Ren, Guosheng; Yang, Dejuan] Chongqing Med Univ, Dept Endocrine & Breast Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Zheng, Hong] Sichuan Univ, Dept Breast Surg, West China Hosp, Chongqing, Peoples R China; [Jiang, Jun] Third Mil Med Univ, Southwest Hosp, Breast Dis Ctr, Chongqing, Peoples R China; [Zou, Tianning] Kunming Med Univ, Dept Breast Surg, Affiliated Hosp 3, Kunming, Yunnan, Peoples R China"

通信作者："Ren, GS; Yang, DJ (通讯作者)，Chongqing Med Univ, Dept Endocrine & Breast Surg, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：MEDICAL SCIENCE MONITOR

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000892697800001

JCR分区：Q2

影响因子：3.1

年份：2022

卷号：28

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Breast Neoplasms; Menarche; Menopause

摘要："BACKGROUND: Reproductive period for women, begins at menarche and ends at menopause, which represented the total time period of exposure to cycling reproductive hormones. The potential associations between clinicopathological features and the exposure of cycling reproductive hormones has not been extensively studied. The retrospective study enrolled 14,731 patients diagnosed with invasive breast cancer was designed to evaluate factors associated with the reproductive period on breast cancer type and patient outcomes.MATERIAL AND METHODS: 14, 731 female breast cancer (BC) patients from Western China Clinical Cooperation Group (WCCCG) between January 1, 2008 to December 31, 2017 were identified. Unconditional logistic regression was performed to assess the associations between clinicopathological features and menarche age, menopause age, and reproductive years. The differences in risk factors between lower and higher number of reproductive years (<35 and (3)35 yrs) were examined with the chi-square test.RESULTS: First, patients with late menarche age were more likely to present with tumors of higher histological grade and larger sizes. Second, the findings suggested a higher likelihood of smaller tumor sizes in postmenopausal patients with a greater length of reproductive years. Conversely, higher histological grade was associated with this group of patients, compared to their counterparts with shorter reproductive years. Third, in luminal breast cancer, patients with a greater length of reproductive years were more probably present larger tumor.CONCLUSIONS: Our findings indicated that several clinicopathologic factors including tumor size and histological grade were associated with the length of reproductive years in patients diagnosed with breast cancer."

基金机构：Western China Clinical Cooperation Group (WCCCG)

基金资助正文：Financial support: This study was supported by the Western China Clinical Cooperation Group (WCCCG)