Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques

作者全名："Tang, Shilong; Liu, Xianfan; Nie, Lisha; Chen, Zhuo; Ran, Qiying; He, Ling"

作者地址："[Tang, Shilong; Liu, Xianfan; Chen, Zhuo; Ran, Qiying; He, Ling] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol,Chongqing Key Lab Pediat,Minist Educ,K, Chongqing, Peoples R China; [Nie, Lisha] GE Healthcare, MR Res China, Beijing, Peoples R China"

通信作者："He, L (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol,Chongqing Key Lab Pediat,Minist Educ,K, Chongqing, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000892741200001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：children; attention-deficit; hyperactivity disorder; magnetic resonance imaging; autistic traits; brain

摘要："ObjectiveTo explore the feasibility of applying quantitative magnetic resonance imaging techniques for the diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs). MethodsA prospective study was performed by selecting 56 children aged 4-5 years with ADHD-ATs as the study group and 53 sex- and age-matched children with ADHD without ATs as the control group. All children underwent magnetic resonance scans with enhanced T2*- weighted magnetic resonance angiography (ESWAN), 3D-PCASL, and 3D-T1 sequences. Iron content and cerebral blood flow parameters were obtained via subsequent software processing, and the parameter values in particular brain regions in both groups were compared and analyzed to determine the characteristics of these parameters in children with ADHD-ATs. ResultsIron content and cerebral blood flow in the frontal lobe, temporal lobe, hippocampus, and caudate nucleus of children with ADHD-ATs were lower than those of children with ADHD without ATs (p < 0.05). Iron content and CBF values in the frontal lobe, temporal lobe and caudate nucleus could distinguish children with ADHD-ATs from those without ATs (AUC > 0.5, p < 0.05). ConclusionsQuantitative magnetic resonance techniques could distinguish children with ADHD-ATs."

基金机构："National Clinical Research Center for Child Health and Disorders (Children's Hospital of Chongqing Medical University, Chongqing, China) [NCRCCHD-2021-YP-07]; Chongqing Municipal Education Commission [KJQN202000425]"

基金资助正文："This study protocol was supported by grants from National Clinical Research Center for Child Health and Disorders (Children's Hospital of Chongqing Medical University, Chongqing, China) (grant number NCRCCHD-2021-YP-07) and Chongqing Municipal Education Commission (No. KJQN202000425)."