Prediction to the prognosis of children with neuroblastoma by nomogram based on the first-diagnosed inflammatory markers

作者全名："Zhang, Yunlong; Zhang, Chenghang; Ma, Yue; Li, Changchun; Zhao, Zhenzhen; Peng, Liang; Deng, Xiaobin; Zhou, Jianwu; Wang, Shan"

作者地址："[Zhang, Yunlong; Zhang, Chenghang; Ma, Yue; Li, Changchun; Zhao, Zhenzhen; Peng, Liang; Deng, Xiaobin; Zhou, Jianwu; Wang, Shan] Chongqing Med Univ, Dept Pediat Surg Oncol, Childrens Hosp, 136 2nd Zhongshan Rd, Chongqing 400010, Peoples R China; [Zhang, Yunlong; Zhang, Chenghang; Ma, Yue; Li, Changchun; Zhao, Zhenzhen; Peng, Liang; Deng, Xiaobin; Zhou, Jianwu; Wang, Shan] Minist Educ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat, Chongqing 400010, Peoples R China"

通信作者："Wang, S (通讯作者)，Chongqing Med Univ, Dept Pediat Surg Oncol, Childrens Hosp, 136 2nd Zhongshan Rd, Chongqing 400010, Peoples R China.; Wang, S (通讯作者)，Minist Educ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat, Chongqing 400010, Peoples R China."

来源：PEDIATRIC SURGERY INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000893012700006

JCR分区：Q2

影响因子：1.8

年份：2022

卷号：39

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Neuroblastoma; Nomogram; Inflammatory markers; Overall survival

摘要："Background: Patients with high-risk neuroblastoma (NB) have a poor prognosis. The prognostic significance of inflammatory biomarker-based nomograms for children with NB has not been previously studied. Methods: Part of patients diagnosed with NB in our center from January 2016 to March 2022 were included in the study. Inflammatory biomarkers were primary outcome measures, including C-reactive protein (CRP), ferritin, neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII). Univariate and multivariate survival analyses were performed to assess the prognostic value of these indicators for overall survival (OS) in NB children, showing the Kaplan-Meier survival curves and plotting the nomogram. C-index were used to detect predictability. Results: 93 NB patients were retrospectively analyzed. CRP, ferritin, NLR, PLR, and SII were significantly associated with OS of NB patients, while LMR were found to be not predictive of OS for NB patients. The established nomogram is well-calibrated, and the C-index is 0.731. Conclusion: Survival analysis found part of inflammatory biomarkers related to the prognosis of NB. The nomogram could be used as a convenient predictive tool in clinical practice to evaluate the prognosis of NB children at first diagnosis."

基金机构："Key Project of ""Research on Prevention and Control of Major Chronic Non-Communicable Diseases""; Ministry of Science and Technology of the People's Republic of China; National Key R&D Program of China [2018YFC1313000, 2018YFC1313004]; General Clinical Medical Research Program of Children's Hospital of Chongqing Medical University [YBXM-2019-003]"

基金资助正文："This work was supported in part by research grants from the Key Project of ""Research on Prevention and Control of Major Chronic Non-Communicable Diseases"", the Ministry of Science and Technology of the People's Republic of China, National Key R&D Program of China (No. 2018YFC1313000, 2018YFC1313004), the General Clinical Medical Research Program of Children's Hospital of Chongqing Medical University (No. YBXM-2019-003)."