Nomogram to predict postoperative complications after cytoreductive surgery for advanced epithelial ovarian cancer: A multicenter retrospective cohort study

作者全名："Jiang, Caixia; Liu, Yingwei; Tang, Junying; Li, Zhengyu; Min, Wenjiao"

作者地址："[Jiang, Caixia; Li, Zhengyu] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu, Peoples R China; [Liu, Yingwei; Tang, Junying] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Min, Wenjiao] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chinese Acad Sci, Psychosomat Dept,Sichuan Translat Med Res Hosp, Chengdu, Peoples R China"

通信作者："Li, ZY (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu, Peoples R China.; Min, WJ (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chinese Acad Sci, Psychosomat Dept,Sichuan Translat Med Res Hosp, Chengdu, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000893370900001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：advanced epithelial ovarian cancer; postoperative complications; cytoreductive surgery; nomogram; predict

摘要："ObjectiveTo establish nomograms to predict the risk of postoperative complications following cytoreductive surgery in patients with advanced epithelial ovarian cancer (AEOC). MethodsA multicenter retrospective cohort study that included patients with FIGO stage IIIC-IV epithelial ovarian cancer who underwent cytoreductive surgery was designed. By using univariate and multivariate analyses, patient preoperative characteristics were used to predict the risk of postoperative complications. Multivariate modeling was used to develop Nomograms. ResultsOverall, 585 AEOC patients were included for analysis (training cohort = 426, extrapolation cohort = 159). According to the findings, the training cohort observed an incidence of postoperative overall and severe complications of 28.87% and 6.10%, respectively. Modified frailty index (mFI) (OR 1.96 and 2.18), FIGO stage (OR 2.31 and 3.22), and Surgical Complexity Score (SCS) (OR 1.16 and 1.23) were the clinical factors that were most substantially associated to the incidence of overall and severe complications, respectively. The resulting nomograms demonstrated great internal discrimination, good consistency, and stable calibration, with C-index of 0.74 and 0.78 for overall and severe complications prediction, respectively. A satisfactory external discrimination was also indicated by the extrapolation cohort, with the C-index for predicting overall and severe complications being 0.92 and 0.91, respectively. ConclusionsThe risk of considerable postoperative morbidity exists after cytoreductive surgery for AEOC. These two nomograms with good discrimination and calibration might be useful to guide clinical decision-making and help doctors assess the probability of postoperative complications for AEOC patients."

基金机构：Department of Science and Technology of Sichuan Province; [21PJ050]

基金资助正文：Funding The Department of Science and Technology of Sichuan Province (grant number 21PJ050).