The Establishment of China Bronchiectasis Registry and Research Collaboration (BE-China): Protocol of a prospective multicenter observational study

作者全名："Gao, Yong-Hua; Lu, Hai-Wen; Mao, Bei; Guan, Wei-Jie; Song, Yuan-Lin; Li, Yuan-Yuan; Wang, Dao-Xin; Wang, Bin; Gu, Hong-Yan; Li, Wen; Luo, Hong; Wang, Ling-Wei; Li, Fan; Guo, Feng-Xia; Zhang, Min; Jie, Zhi-Jun; Hang, Jing-Qing; Yang, Chao; Ren, Tao; Yuan, Zhi; Meng, Qing-Wei; Jia, Qin; Chen, Yu; Chen, Rong-Chang; Qu, Jie-Ming; Xu, Jin-Fu"

作者地址："[Gao, Yong-Hua; Lu, Hai-Wen; Mao, Bei; Xu, Jin-Fu] Tongji Univ, Shanghai Pulm Hosp, Inst Resp Med, Sch Med,Dept Resp & Crit Care Med, 507 Zhengmin Rd, Shanghai 200433, Peoples R China; [Guan, Wei-Jie] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis,State Key Lab Resp Dis, Guangzhou, Peoples R China; [Song, Yuan-Lin] Fudan Univ, Zhongshan Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China; [Li, Yuan-Yuan] Cent South Univ, Xiangya Hosp, Dept Pulm & Crit Care Med, Changsha, Hunan, Peoples R China; [Wang, Dao-Xin] Chongqing Med Univ, Affiliated Hosp 2, Dept Pulm & Crit Care Med, Chongqing, Peoples R China; [Wang, Bin] Huzhou Cent Hosp, Dept Pulm & Crit Care Med, Huzhou, Zhejiang, Peoples R China; [Gu, Hong-Yan] Sixth Peoples Hosp Nantong, Dept Pulm & Crit Care Med, Nantong, Jiangsu, Peoples R China; [Li, Wen] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Resp & Crit Care Med,Key Labora tory Resp Dis, Hangzhou, Zhejiang, Peoples R China; [Luo, Hong] Cent South Univ, Xiangya Hosp 2, Dept Resp & Crit Care Med, Changsha, Hunan, Peoples R China; [Wang, Ling-Wei; Chen, Rong-Chang] Shenzhen Peoples Hosp, Shenzhen Inst Resp Dis, Pulm & Crit Care Dept, Shenzhen 518020, Guangdong, Peoples R China; [Li, Fan] Songjiang Dist Cent Hosp, Dept Resp & Crit Care Med, Shanghai, Peoples R China; [Guo, Feng-Xia] Eighth Peoples Hosp Shanghai, Dept Resp & Crit Care Med, Shanghai, Peoples R China; [Zhang, Min] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Resp & Crit Care Med, Shanghai, Peoples R China; [Jie, Zhi-Jun] Fudan Univ, Shanghai Peoples Hosp 5, Dept Resp & Crit Care Med, Shanghai, Peoples R China; [Hang, Jing-Qing] Shanghai Putuo Dist Peoples Hosp, Dept Resp & Crit Care Med, Shanghai, Peoples R China; [Yang, Chao] Suzhou Sci & Technol Town Hosp, Dept Resp & Crit Care Med, Suzhou, Peoples R China; [Ren, Tao] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Resp & Crit Care Med, Shanghai, Peoples R China; [Yuan, Zhi] Fenghua Dist Peoples Hosp, Dept Resp & Crit Care Med, Ningbo, Zhejiang, Peoples R China; [Meng, Qing-Wei] Shangrao Peoples Hosp, Dept Resp & Crit Care Med, Shangrao, Jiangxi, Peoples R China; [Jia, Qin] Shidong Hosp Yangpu Dist, Dept Resp & Crit Care Med, Shanghai, Peoples R China; [Chen, Yu] China Med Univ, Shengjing Hosp, Dept Resp & Crit Care Med, Shenyang, Peoples R China; [Qu, Jie-Ming] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Resp & Crit Care Med, Shanghai 200025, Peoples R China"

通信作者："Xu, JF (通讯作者)，Tongji Univ, Shanghai Pulm Hosp, Inst Resp Med, Sch Med,Dept Resp & Crit Care Med, 507 Zhengmin Rd, Shanghai 200433, Peoples R China.; Chen, RC (通讯作者)，Shenzhen Peoples Hosp, Shenzhen Inst Resp Dis, Pulm & Crit Care Dept, Shenzhen 518020, Guangdong, Peoples R China.; Qu, JM (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Resp & Crit Care Med, Shanghai 200025, Peoples R China."

来源：RESPIRATORY RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000893414500004

JCR分区：Q1

影响因子：5.8

年份：2022

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Bronchiectasis; Registry; Real-world study; Protocol; BE-China

摘要："Background: Bronchiectasis is a highly heterogeneous chronic airway disease with marked geographic and ethnic variations. Most influential cohort studies to date have been performed in Europe and USA, which serve as the examples for developing a cohort study in China where there is a high burden of bronchiectasis. The Establishment of China Bronchiectasis Registry and Research Collaboration (BE-China) is designed to: (1) describe the clinical characteristics and natural history of bronchiectasis in China and identify the differences of bronchiectasis between the western countries and China; (2) identify the risk factors associated with disease progression in Chinese population; (3) elucidate the phenotype and endotype of bronchiectasis by integrating the genome, microbiome, proteome, and transcriptome with detailed clinical data; (4) facilitate large randomized controlled trials in China. Methods: The BE-China is an ongoing prospective, longitudinal, multi-center, observational cohort study aiming to recruit a minimum of 10,000 patients, which was initiated in January 2020 in China. Comprehensive data, including medical history, aetiological testing, lung function, microbiological profiles, radiological scores, comorbidities, mental status, and quality of life (QoL), will be collected at baseline. Patients will be followed up annually for up to 10 years to record longitudinal data on outcomes, treatment patterns and QoL. Biospecimens, if possible, will be collected and stored at - 80 & DEG;C for further research. Up to October 2021, the BE-China has enrolled 3758 patients, and collected 666 blood samples and 196 sputum samples from 91 medical centers. The study protocol has been approved by the Shanghai Pulmonary Hospital ethics committee, and all collaborating centers have received approvals from their local ethics committee. All patients will be required to provide written informed consent to their participation. Conclusions: Findings of the BE-China will be crucial to reveal the clinical characteristics and natural history of bronchiectasis and facilitate evidence-based clinical practice in China."

基金机构："National Natural Science Foundation of China; Innovation Program of Shanghai Municipal Education Commission [81925001, 82270047]; Program of Shanghai Municipal Science and Technology Commission [202101070007-E00097]; Innovative research team of high-level local universities in Shanghai and Innovative team of Shanghai Pulmonary Hospital [21DZ2201800]"

基金资助正文：This work was supported by the National Natural Science Foundation of China (81925001 to JFX; 82270047 to YHG); the Innovation Program of Shanghai Municipal Education Commission (202101070007-E00097); Program of Shang-hai Municipal Science and Technology Commission (21DZ2201800); Innova-tive research team of high-level local universities in Shanghai and Innovative team of Shanghai Pulmonary Hospital.