Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in people with gastrointestinal cancer

作者全名："Li, Tong; Song, Rui; Wang, Jingjie; Zhang, Jianbo; Cai, Hongxing; He, Hongmei; Hu, Wei; Yu, Dajun; Wang, Chuanhu; Pan, Qingbo; Peng, Mingli; Ren, Hong; Zhu, Peng"

作者地址："[Li, Tong; Zhang, Jianbo; Cai, Hongxing; He, Hongmei; Zhu, Peng] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Pan, Qingbo; Peng, Mingli; Ren, Hong] Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Minist Educ,Affiliate, Chongqing, Peoples R China; [Hu, Wei; Yu, Dajun; Wang, Chuanhu] Renmin Hosp Wushan Country, Dept Gen Surg, Chongqing, Peoples R China"

通信作者："Zhu, P (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China.; Ren, H (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Minist Educ,Affiliate, 74 Linjiang Rd, Chongqing 010, Peoples R China."

来源：INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000893664700001

JCR分区：Q1

影响因子：8.4

年份：2022

卷号：122

期号：　

开始页：874

结束页：884

文献类型：Article

关键词：COVID-19; Inactivated vaccine; Memory B cells

摘要："Objectives: This study aimed to evaluate the safety and immunogenicity of inactivated COVID-19 vaccines in patients with gastrointestinal cancer (GI) cancer. The role of memory B cells (MBCs) in the humoral response to COVID-19 vaccination was also investigated. Methods: In this prospective observational study, GI cancer patients and healthy individuals who had received 2 doses of inactivated COVID-19 vaccines were included. The data regarding adverse effects, serum anti-receptor binding domain (RBD)-IgG, neutralizing antibodies (NAbs), and frequencies of MBCs were collected prospectively. Results: The inactivated COVID-19 vaccines were safe and well tolerated. Serum anti-RBG-IgG and NAbs were lower for cancer patients. Old age, high ASA score, and receiving active chemotherapy were risk factors for lower antibody titers. The frequencies of activated and resting MBCs decreased in (17.45% vs 38.11%, P = 0.002; 16.98% vs 34.13%, P = 0.023), while the frequencies of intermediate and atypical MBCs increased in cancer patients (40.06% vs 19.87%, P = 0.010; 25.47% vs 16.61%, P = 0.025). The serum antibody titer decreased gradually during follow-up but increased when a booster vaccine was given. Conclusion: The inactivated COVID-19 vaccines were well tolerated in patients with GI cancer but with lower immunogenicity. The subpopulations of MBCs were disordered in cancer patients, and a booster vaccine may be prioritized for them."

基金机构："National Science and Technology Major Project of China [2017ZX10202203-007, 2018ZX10302206-003]; National Natural Science Foundation of China [81772198]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0389]; KuanRen Excellent Doctor project [kryc-yq-2220, ky2019y008]"

基金资助正文："This work is supported by the National Science and Technology Major Project of China (2017ZX10202203-007, 2018ZX10302206-003). We also acknowledge the support of the National Natural Science Foundation of China (81772198), Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0389), KuanRen Excellent Doctor project (kryc-yq-2220; ky2019y008)"