Incidence and timing of coronary thrombosis in Kawasaki disease patients with giant coronary artery aneurysm

作者全名："Peng, Yue; Yi, Qijian"

作者地址："[Peng, Yue; Yi, Qijian] Chongqing Med Univ, Dept Cardiovasc Med, Childrens Hosp, Chongqing 400014, Peoples R China"

通信作者："Yi, QJ (通讯作者)，Chongqing Med Univ, Dept Cardiovasc Med, Childrens Hosp, Chongqing 400014, Peoples R China."

来源：THROMBOSIS RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000896015800006

JCR分区：Q1

影响因子：3.7

年份：2023

卷号：221

期号：　

开始页：30

结束页：34

文献类型：Article

关键词：Kawasaki disease; Giant coronary artery aneurysm; Thrombosis; Risk factors

摘要："Objective: Coronary thrombosis is a common cardiovascular complication of Kawasaki disease (KD), which seriously affects the long-term therapeutic effect of KD. The purpose was to determine the incidence and timing of coronary thrombosis and to identify risk factors for coronary thrombosis in KD with giant coronary artery aneurysm (GCAA). Methods and results: A total of 94 consecutive KD patients with GCAA from Children's Hospital Affiliated to Chongqing Medical University were enrolled retrospectively. The cumulative incidence of coronary thrombosis in KD patients with GCAA was 59 % (n = 54). Coronary thrombosis mainly occurred in the acute phase (n = 41/54, 76 %), with a median time of 16 days after onset. Cox regression analysis was used to identify risk factors for coronary thrombosis. Cox regression analysis indicated that male (hazard ratios, 1.87; 95 % CI, 1.01-3.44; P = 0.43), left anterior descending artery (LAD) involvement (hazard ratios, 3.75; 95 % CI, 1.85-7.39; P < 0.001), coronary absolute diameter >= 8 mm (hazard ratios, 2.93; 95 % CI, 1.36-6.29; P = 0.006) constituted a higher risk of coronary thrombosis after adjusting for confounders. Kaplan-Meier method showed the cumulative incidence for coronary thrombosis in KD patients with GCAA was 79 %, 92 %, and 88 % in male, LAD involvement, coronary absolute diameter > 8 mm, respectively. Conclusions: Male, LAD involvement, and coronary absolute diameter >= 8 mm were associated with a high incidence of coronary thrombosis. Based on the analysis of the incidence, time and risk factors of coronary thrombosis in different periods, this study may provide an essential reference for thromboprophylaxis man-agement of KD with GCAA."

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