"Efficacy and mechanisms of 4-week MBSR on psychological distress in lung cancer patients: A single-center, single-blind, longitudinal, randomized controlled trial"
作者全名："Tian, Xu; Liao, Zhongli; Yi, Lijuan; Tang, Ling; Chen, Guihua; Herrera, Maria F. Jimenez"
作者地址："[Tian, Xu; Yi, Lijuan; Herrera, Maria F. Jimenez] Univ Rvoira & Virgili, Nursing Dept, Tarragona, Spain; [Liao, Zhongli; Tang, Ling] Chongqing Univ Canc Hosp, Chongqing, Peoples R China; [Chen, Guihua] Chongqing Med Univ, Affiliated Hosp 2, Dept Nursing, Chongqing, Peoples R China"
通信作者："Herrera, MFJ (通讯作者)，Univ Rvoira & Virgili, Nursing Dept, Tarragona, Spain.; Chen, GH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Nursing, Chongqing, Peoples R China."
来源：ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
关键词：Lung cancer; Psychological distress; Mindfulness; MBSR; Structural equation modeling
摘要："Objective: This study aimed to evaluate the efficacy of a 4-week mindfulness-based stress reduction (MBSR) program on psychological distress in patients with lung cancer and elucidate its mechanisms.Methods: This single-center, single-blinded, longitudinal, randomized controlled trial was conducted on 175 pa-tients with lung cancer randomly allocated to a 4-week MBSR or a waiting-list group. The efficacy and mecha-nisms of the 4-week MBSR program were evaluated by outcome measures at preintervention (T0), the immediate postintervention (T1), 1 month (T2), and 3 months (T3). We analyzed the collected data using the per-protocol set principle, independent sample t-test, repeated measure analysis of variance, and structural equation modeling.Results: The 4-week MBSR program significantly alleviated psychological distress (F = 15.05, P < 0.001), decreased perceived stigma (F = 8.260, P = 0.005), improved social support (F = 16.465, P < 0.001), and enhanced mindfulness (F = 17.207, P < 0.001) compared with usual care at T1, T2, and T3. All variables significantly changed over time except for copying style (P = 0.250). The changes in social support, mindfulness, and perceived stigma mediated the efficacy of the 4-week MBSR program on psychological distress (beta = -0.292, P = 0.005; beta = -0.358, P = 0.005). Conclusions: This study shows the benefits of the MBSR program for psychological distress, social support, mindfulness, and perceived stigma in patients with lung cancer. Also, it elucidates the mechanisms by which the MBSR program alleviates psychological distress by improving social support, enhancing mindfulness, and decreasing perceived stigma. The findings provide insights into applying the MBSR program to reduce psycho-logical distress among patients with lung cancer."
基金机构：Chongqing Natural Science Foun-dation; Basic Science and Frontier Technology Research Project of Chongqing; Medical Research Project; Chongqing Science and Technology Bureau and Health Commission of Chongqing Municipal City; [cstc2020jcyj-msxmX0212]; [cstc2048jcyjAX0775]; [2022MSXM067]
基金资助正文："Funding This study was supported by the Chongqing Natural Science Foun-dation (Grant No. cstc2020jcyj-msxmX0212) , the Basic Science and Frontier Technology Research Project of Chongqing (Grant No. cstc2048jcyjAX0775) , and the Medical Research Project which was jointly approved by the Chongqing Science and Technology Bureau and Health Commission of Chongqing Municipal City (Grant No. 2022MSXM067) ."