Urea Synthesis from Isocyanides and O-Benzoyl Hydroxylamines Catalyzed by a Copper Salt

作者全名："Yu, Ning; Lv, Jing-Fang; He, Shi-Mei; Cui, Yanyan; Wei, Ye; Jiang, Kun"

作者地址："[Yu, Ning; Lv, Jing-Fang; He, Shi-Mei; Wei, Ye; Jiang, Kun] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China; [Cui, Yanyan] Chongqing Med Univ, Dept Cell Biol & Genet, Chongqing 400016, Peoples R China"

通信作者："Wei, Y; Jiang, K (通讯作者)，Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China.; Cui, YY (通讯作者)，Chongqing Med Univ, Dept Cell Biol & Genet, Chongqing 400016, Peoples R China."

来源：MOLECULES

ESI学科分类：CHEMISTRY

WOS号：WOS:000897383500001

JCR分区：Q2

影响因子：4.6

年份：2022

卷号：27

期号：23

开始页：　

结束页：　

文献类型：Article

关键词：copper catalysis; isocyanides; hydroxylamines; ureas; insertion

摘要："In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv t-BuONa or PhONa, 30 degrees C), using aryl isocyanides and O-benzoyl hydroxylamines as the readily accessible starting materials. The reactions might undergo a cascade process involving isocyanide insertion into the N-O bond and Mumm-type rearrangement. This work represents a rare example of isocyanide insertion into N-O bonds, which would extend isocyanide insertion chemistry."

基金机构："National Science Foundation of China [22271237, 21772231]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxm2042]; Key Project of Innovation Research Pilot Plan of Southwest University [SWU-XDZD22007]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202200222, KJZD-K202200201]; Southwest University [SWU118129, SWU120046]"

基金资助正文："This research was funded by National Science Foundation of China (No. 22271237, 21772231), Natural Science Foundation of Chongqing (No. cstc2020jcyj-msxm2042), Key Project of Innovation Research 2035 Pilot Plan of Southwest University (No. SWU-XDZD22007), Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJQN202200222, KJZD-K202200201), and Southwest University (No. SWU118129, SWU120046)."