Contributions of SGK3 to transporter-related diseases
作者全名："Liao, Qian-Qian; Dong, Qing-Qing; Zhang, Hui; Shu, Hua-Pan; Tu, Yu-Chi; Yao, Li-Jun"
作者地址："[Liao, Qian-Qian; Dong, Qing-Qing; Zhang, Hui; Shu, Hua-Pan; Tu, Yu-Chi; Yao, Li-Jun] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China; [Dong, Qing-Qing] Chongqing Med Univ, Affiliated Hosp 2, Dept Nephrol, Chongqing, Peoples R China"
通信作者："Yao, LJ (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China."
来源：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
关键词：serum- and glucocorticoid-induced kinase; SGK3; channel; substance metabolism; substance transport
摘要："Serum- and glucocorticoid-induced kinase 3 (SGK3), which is ubiquitously expressed in mammals, is regulated by estrogens and androgens. SGK3 is activated by insulin and growth factors through signaling pathways involving phosphatidylinositol-3-kinase (PI3K), 3-phosphoinositide-dependent kinase-1 (PDK-1), and mammalian target of rapamycin complex 2 (mTORC2). Activated SGK3 can activate ion channels (TRPV5/6, SOC, Kv1.3, Kv1.5, Kv7.1, BKCa, Kir2.1, Kir2.2, ENaC, Nav1.5, ClC-2, and ClC Ka), carriers and receptors (Npt2a, Npt2b, NHE3, GluR1, GluR6, SN1, EAAT1, EAAT2, EAAT4, EAAT5, SGLT1, SLC1A5, SLC6A19, SLC6A8, and NaDC1), and Na+/K+-ATPase, promoting the transportation of calcium, phosphorus, sodium, glucose, and neutral amino acids in the kidney and intestine, the absorption of potassium and neutral amino acids in the renal tubules, the transportation of glutamate and glutamine in the nervous system, and the transportation of creatine. SGK3-sensitive transporters contribute to a variety of physiological and pathophysiological processes, such as maintaining calcium and phosphorus homeostasis, hydro-salinity balance and acid-base balance, cell proliferation, muscle action potential, cardiac and neural electrophysiological disturbances, bone density, intestinal nutrition absorption, immune function, and multiple substance metabolism. These processes are related to kidney stones, hypophosphorous rickets, multiple syndromes, arrhythmia, hypertension, heart failure, epilepsy, Alzheimer's disease, amyotrophic lateral sclerosis, glaucoma, ataxia idiopathic deafness, and other diseases."
基金机构：National Natural Science foundation of China; 
基金资助正文：Funding This work was supported by the fund from the National Natural Science foundation of China (No. 81974102).