Exploring the causal relationship between gastroesophageal reflux and oral lesions: A mendelian randomization study

作者全名："Shu, Linjing; Tong, Xu"

作者地址："[Shu, Linjing; Tong, Xu] Chongqing Med Univ, Stomatol Hosp, Chongqing, Peoples R China; [Shu, Linjing; Tong, Xu] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Tong, Xu] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China"

通信作者："Tong, X (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing, Peoples R China.; Tong, X (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China.; Tong, X (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China."

来源：FRONTIERS IN GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000898505400001

JCR分区：Q2

影响因子：3.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：mendelian randomization; causal relationship; gastroesophageal reflux disease; oral disease; periodontitis; toothache; oral ulcer

摘要："Background: Clinical observations and retrospective studies have observed that patients with gastroesophageal reflux disease (GERD) have an increased probability of dental erosion, periodontitis and oral mucosal lesions and other common oral lesions. However, whether there is a genetic causal relationship between GERD and the occurrence of oral lesions has not been reported. Methods: In this study, we extracted instrumental variables from the largest published summary statistics of the oral lesion phenotype GWAS in UK Biobank (UKBB) and GERD GWAS. Then, we performed a causal inference analysis between GERD and common oral lesions by mendelian randomization (MR) analysis with the R package ""TwoSampleMR "". Results: We observed a significant causal relationship between GERD and several common oral lesion phenotypes (painful gums, loose teeth, toothache, and mouth ulcers). GERD showed a positive correlation with the occurrence of these oral lesions. After removing outlier SNPs via the MR-PRESSO package, our conclusions were still robust. Conclusion: Our findings provide the first evidence for a genetic causal effect of GERD on oral lesion pathogenesis. For patients with confirmed GERD, attention should be paid to taking interventions to prevent the occurrence of oral lesions."

基金机构：Innovation Team Building at Institutions of Higher Education in Chongqing in 2016

基金资助正文：The authors acknowledge the financial support received from the Innovation Team Building at Institutions of Higher Education in Chongqing in 2016.