Triboelectric nanogenerators stimulated electroacupuncture (EA) treatment for promoting the functional recovery after spinal cord injury

作者全名："Wei, Xuelian; Wang, Yunhang; Tan, Botao; Zhang, Enyang; Wang, Baocheng; Su, Hong; Yu, Lehua; Yin, Ying; Wang, Zhong Lin; Wu, Zhiyi"

作者地址："[Wei, Xuelian; Zhang, Enyang; Wang, Baocheng; Wang, Zhong Lin; Wu, Zhiyi] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China; [Wei, Xuelian; Zhang, Enyang; Wang, Baocheng; Wang, Zhong Lin; Wu, Zhiyi] Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China; [Wang, Yunhang; Tan, Botao; Su, Hong; Yu, Lehua; Yin, Ying] Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Chongqing 400010, Peoples R China; [Wang, Zhong Lin] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA"

通信作者："Wang, ZL; Wu, ZY (通讯作者)，Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China.; Wang, ZL; Wu, ZY (通讯作者)，Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China.; Yin, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Chongqing 400010, Peoples R China.; Wang, ZL (通讯作者)，Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA."

来源：MATERIALS TODAY

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000898940600012

JCR分区：Q1

影响因子：24.2

年份：2022

卷号：60

期号：　

开始页：41

结束页：51

文献类型：Article

关键词：Spinal cord injury; Electroacupuncture; Acupoints; Triboelectric nanogenerator; Direct electrostimulation

摘要："Electroacupuncture (EA), as a particular type of electrostimulation treatment, has an extensive application in the field of biomedicine. Triboelectric nanogenerator (TENG) has sparked significant concern attributed to the high electrical output with low cost, whose electrical signals can also be directly usable for electrical stimulation. Here we propose a Chinese medicine EA treatment with the assistance of TENG technology, in which a bidirectional continuous current from a soft-contact freestanding rotary TENG (FR-TENG) is applied to two effective acupoints of rats by inserting electric needles. The TENG-driven EA treatment promotes the performance of gait 2 weeks after as well as the Basso-Beattie-Bresnahan (BBB) score. This elevation last as long as 4 weeks post injury. Moreover, the TENG-driven EA treatment enhances neuron survival in the ventral horn and inhibits astrocyte activation in the lesion site. Therefore, the TENG-driven EA treatment provides a significant neuroprotection effect on spinal cord contusion in rats. Our studies not only demonstrate the possibility of the TENG-driven EA treatment for traumatic central nervous system injuries but also provide an experimental basis for the prevention and treatment of diseases by traditional Chinese medicine treatment."

基金机构："State Key Laboratory of Trauma, Burns and Combined Injury, Department of Research Institute of Surgery, Daping Hospital, Army Military Medical University; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University; National Natural Science Foundation of China [81702221, 82002377]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxm0651, cstc2019jcyj-msxmX0195]"

基金资助正文："The authors sincerely appreciate the experimental platform support of the State Key Laboratory of Trauma, Burns and Combined Injury, Department of Research Institute of Surgery, Daping Hospital, Army Military Medical University. We thank Prof. Yuan Liu and Prof. Ce Yang for their advice on the current project. Botao Tan and Ying Yin were supported by the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University. This work was supported in part by the: National Natural Science Foundation of China (No. 81702221, No. 82002377); Natural Science Foundation of Chongqing (No. cstc2020jcyj-msxm0651, cstc2019jcyj-msxmX0195)."