"The relationship between hair metabolites, air pollution exposure and gestational diabetes mellitus: A longitudinal study from pre-conception to third trimester"

作者全名："Chen, Xuyang; Zhao, Xue; Jones, Mary Beatrix; Harper, Alexander; de Seymour, Jamie V.; Yang, Yang; Xia, Yinyin; Zhang, Ting; Qi, Hongbo; Gulliver, John; Cannon, Richard D.; Saffery, Richard; Zhang, Hua; Han, Ting-Li; Baker, Philip N."

作者地址："[Chen, Xuyang; Zhao, Xue; Yang, Yang; Zhang, Ting; Qi, Hongbo; Zhang, Hua] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China; [Chen, Xuyang; Zhao, Xue; Yang, Yang; Zhang, Ting; Qi, Hongbo; Zhang, Hua; Han, Ting-Li] Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing, Peoples R China; [Jones, Mary Beatrix] Univ Auckland, Dept Stat, Auckland, New Zealand; [Harper, Alexander] Univ Leicester, Dept Hlth Sci, Leicester, England; [de Seymour, Jamie V.] Massey Univ, Coll Hlth, Auckland, New Zealand; [Xia, Yinyin] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Zhang, Ting] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Gulliver, John] Univ Leicester, Ctr Environm Hlth & Sustainabil, Leicester, England; [Cannon, Richard D.] Univ Otago, Sir John Walsh Res Inst, Fac Dent, Dept Oral Sci, Dunedin, New Zealand; [Saffery, Richard] Royal Childrens Hosp, Murdoch Childrens Res Inst, Mol Immun, Melbourne, Vic, Australia; [Han, Ting-Li] Univ Auckland, Liggins Inst, Auckland, New Zealand; [Han, Ting-Li] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, Chongqing, Peoples R China; [Baker, Philip N.] Univ Leicester, Coll Life Sci, Leicester, England"

通信作者："Zhang, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.; Zhang, H; Han, TL (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing, Peoples R China.; Han, TL (通讯作者)，Univ Auckland, Liggins Inst, Auckland, New Zealand.; Han, TL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000899043700001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：gestational diabetes mellitus; cohort study; metabolomics; hair analysis; air pollution

摘要："BackgroundGestational diabetes mellitus (GDM) is a metabolic condition defined as glucose intolerance with first presentation during pregnancy. Many studies suggest that environmental exposures, including air pollution, contribute to the pathogenesis of GDM. Although hair metabolite profiles have been shown to reflect pollution exposure, few studies have examined the link between environmental exposures, the maternal hair metabolome and GDM. The aim of this study was to investigate the longitudinal relationship (from pre-conception through to the third trimester) between air pollution exposure, the hair metabolome and GDM in a Chinese cohort. MethodsA total of 1020 women enrolled in the Complex Lipids in Mothers and Babies (CLIMB) birth cohort were included in our study. Metabolites from maternal hair segments collected pre-conception, and in the first, second, and third trimesters were analysed using gas chromatography-mass spectrometry (GC-MS). Maternal exposure to air pollution was estimated by two methods, namely proximal and land use regression (LUR) models, using air quality data from the air quality monitoring station nearest to the participant's home. Logistic regression and mixed models were applied to investigate associations between the air pollution exposure data and the GDM associated metabolites. ResultsOf the 276 hair metabolites identified, the concentrations of fourteen were significantly different between GDM cases and non-GDM controls, including some amino acids and their derivatives, fatty acids, organic acids, and exogenous compounds. Three of the metabolites found in significantly lower concentrations in the hair of women with GDM (2-hydroxybutyric acid, citramalic acid, and myristic acid) were also negatively associated with daily average concentrations of PM2.5, PM10, SO2, NO2, CO and the exposure estimates of PM2.5 and NO2, and positively associated with O-3. ConclusionsThis study demonstrated that the maternal hair metabolome reflects the longitudinal metabolic changes that occur in response to environmental exposures and the development of GDM."

基金机构："National Natural Science Foundation of China [81871185, 81971406]; 111 Project [Yuwaizhuan (2016)32]; Chongqing Science & Technology Commission [cstc2021jcyj-msxmX0213, 2021MSXM121, 2020MSXM101]; Chongqing Municipal Education Commission [KJZD-K202100407]; Chongqing Health Commission"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81971406, 81871185), The 111 Project (Yuwaizhuan (2016)32), Chongqing Science & Technology Commission (cstc2021jcyj-msxmX0213), Chongqing Municipal Education Commission (KJZD-K202100407), Chongqing Health Commission and Chongqing Science & Technology Commission (2021MSXM121, 2020MSXM101)."