CK1 alpha upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells

作者全名："Xiong, Jing; Jiang, Yanjun; Zhang, Jinru; Chen, Yanmeng; Hu, Yuan"

作者地址："[Xiong, Jing; Jiang, Yanjun; Zhang, Jinru; Chen, Yanmeng; Hu, Yuan] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China"

通信作者："Hu, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China."

来源：VIROLOGICA SINICA

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000899678100001

JCR分区：Q3

影响因子：5.5

年份：2022

卷号：37

期号：6

开始页：894

结束页：903

文献类型：Article

关键词：Hepatitis B virus (HBV); Casein kinase 1? (CK1?); Interferon-?; ? receptor 1 (IFNAR1); Interferon-? (IFN-?)

摘要："Casein kinase 1 alpha (CK1 alpha) mediates the phosphorylation and degradation of interferon-alpha/beta receptor 1 (IFNAR1) in response to viral infection. However, how CK1 alpha regulates hepatitis B virus (HBV) replication and the anti-HBV effects of IFN-alpha are less reported. Here we show that CK1 alpha can interact with IFNAR1 in hepatoma carcinoma cells and increased the abundance of IFNAR1 by reducing the ubiquitination levels in the presence of HBV. Furthermore, CK1 alpha promotes the IFN-alpha triggered JAK-STAT signaling pathway and consequently enhances the antiviral effects of IFN-alpha against HBV replication. Our results collectively provide evidence that CK1 alpha positively regulates the anti-HBV activity of IFN-alpha in hepatoma carcinoma cells, which would be a promising therapeutic target to improve the effectiveness of IFN-alpha therapy to cure CHB."

基金机构：National Key Research and Devel-opment Program of China; Natural Science Foundation Project of Science and Technology Agency of Chongqing YuZhong District; Natural Science Foundation Project of CQ CSTC; [2018YFE0107500]; [20200122]; [cstc2021jcyj-msxmX0276]

基金资助正文：Acknowledgments This work was supported by the National Key Research and Devel-opment Program of China (2018YFE0107500) and the Natural Science Foundation Project of Science and Technology Agency of Chongqing YuZhong District (20200122) to Hu Yuan; a Natural Science Foundation Project of CQ CSTC (cstc2021jcyj-msxmX0276) to Chen YanMeng.