A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder

作者全名："Li, Qi; Cai, Miao; Pu, Qingsong; Wu, Shengde; Liu, Xing; Lin, Tao; He, Dawei; Wen, Jianguo; Wei, Guanghui"

作者地址："[Li, Qi; Cai, Miao; Wu, Shengde; Liu, Xing; Lin, Tao; He, Dawei; Wei, Guanghui] Childrens Hosp Chongqing Med Univ, Dept Urol, Chongqing, Peoples R China; [Li, Qi; Cai, Miao; Wu, Shengde; Liu, Xing; Lin, Tao; He, Dawei; Wei, Guanghui] China Int Sci & Technol Cooperat Base Child Dev &, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing Key Lab Pediat,Minist Educ Key Lab Child, Chongqing, Peoples R China; [Pu, Qingsong; Wen, Jianguo] First Affiliated Hosp Zhengzhou Univ, Henan Joint Int Pediat Urodynam Ctr, Zhengzhou, Peoples R China"

通信作者："Wei, GH (通讯作者)，Childrens Hosp Chongqing Med Univ, Dept Urol, Chongqing, Peoples R China.; Wei, GH (通讯作者)，China Int Sci & Technol Cooperat Base Child Dev &, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing Key Lab Pediat,Minist Educ Key Lab Child, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000900753300001

JCR分区：Q1

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：child; neurogenic bladder; upper urinary tract damage; nomogram; logistic regression

摘要："PurposeTo establish a predictive model for upper urinary tract damage (UUTD) in children with neurogenic bladder (NB) and verify its efficacy. MethodsA retrospective study was conducted that consisted of a training cohort with 167 NB patients and a validation cohort with 100 NB children. The clinical data of the two groups were compared first, and then univariate and multivariate logistic regression analyses were performed on the training cohort to identify predictors and develop the nomogram. The accuracy and clinical usefulness of the nomogram were verified by receiver operating characteristic (ROC) curve, calibration curve and decision curve analyses. ResultsThere were no significant differences in other parameters between the training and validation cohorts except for age (all P > 0.05). Recurrent urinary tract infection, bladder compliance, detrusor leak point pressure, overactive bladder and clean intermittent catheterization were identified as predictors and assembled into the nomogram. The nomogram showed good discrimination with the area under the ROC curve (AUC) in the training cohort (0.806, 95% CI: 0.737-0.874) and validation cohort (0.831, 95% CI: 0.753-0.0.909). The calibration curve showed that the nomograms were well calibrated, with no significant difference between the predicted and observed probabilities. Decision curve analysis indicated that the nomogram has good clinical applicability. ConclusionThis study presents an effective nomogram incorporating five clinical characteristics that can be conveniently applied to assess NB children' risk of progressing to UUTD."

基金机构："National Natural Science Foundation of China [U1904208]; National Clinical Research Center for Child Health, General Program of Clinical Research [NCRCCHD-2020-GP-04]"

基金资助正文："This work was supported by National Natural Science Foundation of China (U1904208); National Clinical Research Center for Child Health, General Program of Clinical Research (NCRCCHD-2020-GP-04)"