Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice

作者全名："Gao, Feng-Xia; Wu, Rui-Xin; Shen, Mei-Ying; Huang, Jing-Jing; Li, Ting-Ting; Hu, Chao; Luo, Fei-Yang; Song, Shu-Yi; Mu, Song; Hao, Ya-Nan; Han, Xiao-Jian; Wang, Ying-Ming; Li, Luo; Li, Sheng-Long; Chen, Qian; Wang, Wang; Jin, Ai-Shun"

作者地址："[Gao, Feng-Xia; Wu, Rui-Xin; Huang, Jing-Jing; Li, Ting-Ting; Hu, Chao; Luo, Fei-Yang; Song, Shu-Yi; Mu, Song; Hao, Ya-Nan; Han, Xiao-Jian; Wang, Ying-Ming; Li, Luo; Li, Sheng-Long; Chen, Qian; Wang, Wang; Jin, Ai-Shun] Chongqing Med Univ, Coll Basic Med, Dept Immunol, Chongqing 400010, Peoples R China; [Gao, Feng-Xia; Wu, Rui-Xin; Huang, Jing-Jing; Li, Ting-Ting; Hu, Chao; Luo, Fei-Yang; Song, Shu-Yi; Mu, Song; Hao, Ya-Nan; Han, Xiao-Jian; Wang, Ying-Ming; Li, Luo; Li, Sheng-Long; Chen, Qian; Wang, Wang; Jin, Ai-Shun] Chongqing Med Univ, Chongqing Key Lab Basic & Translat Res Tumor Immun, Chongqing 400010, Peoples R China; [Shen, Mei-Ying] Chongqing Med Univ, Dept Endocrine Breast Surg, Affiliated Hosp 1, Chongqing 400010, Peoples R China"

通信作者："Wang, W; Jin, AS (通讯作者)，Chongqing Med Univ, Coll Basic Med, Dept Immunol, Chongqing 400010, Peoples R China.; Wang, W; Jin, AS (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Basic & Translat Res Tumor Immun, Chongqing 400010, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:000901568200005

JCR分区：Q1

影响因子：5.8

年份：2022

卷号：25

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："The repetitive applications of vaccine boosters have been brought up in face of continuous emergence of SARS-CoV-2 variants with neutralization escape mutations, but their protective efficacy and potential adverse effects remain largely unknown. Here, we compared the humoral and cellular immune responses of an extended course of recombinant receptor binding domain (RBD) vaccine boosters with those from conventional immunization strategy in a Balb/c mice model. Multiple vaccine boosters after the conventional vaccination course significantly decreased RBD-specific antibody titers and serum neutralizing efficacy against the Delta and Omicron variants, and profoundly impaired CD4(+) and CD8(+)T cell activation and increased PD-1 and LAG-3 expressions in these T cells. Mechanistically, we confirmed that extended vaccination with RBD boosters overturned the protective immune memories by promoting adaptive immune tolerance. Our findings demonstrate potential risks with the continuous use of SAPS-CoV-2 vaccine boosters, providing immediate implications for the global COVID-19 vaccination enhancement strategies."

基金机构：SARS-CoV-2 Virus Emergency Research Project of Chongqing Medical University

基金资助正文：The study was supported by SARS-CoV-2 Virus Emergency Research Project of Chongqing Medical University.