Association between triglyceride-glucose index and atrial fibrillation: A retrospective observational study

作者全名："Chen, Shengnan; Mei, Qiao; Guo, Li; Yang, Xiaoli; Luo, Wenbin; Qu, Xuemei; Li, Xiaoping; Zhou, Bingqing; Chen, Ken; Zeng, Chunyu"

作者地址："[Chen, Shengnan; Mei, Qiao; Zeng, Chunyu] ChongQing Med Univ, Chongqing, Peoples R China; [Chen, Shengnan; Mei, Qiao; Yang, Xiaoli; Luo, Wenbin; Li, Xiaoping; Zhou, Bingqing; Zeng, Chunyu] Third Mil Med Univ, Army Med Univ, Daping Hosp, Dept Cardiol, Chongqing, Peoples R China; [Chen, Shengnan; Mei, Qiao; Chen, Ken; Zeng, Chunyu] Univ Chinese Acad Sci, Chinese Acad Sci, Cardiovasc Res Ctr Chongqing Coll, Chongqing, Peoples R China; [Guo, Li] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China; [Yang, Xiaoli; Luo, Wenbin; Li, Xiaoping; Zhou, Bingqing; Zeng, Chunyu] Chongqing Cardiovasc Clin Res Ctr Chongqing Inst C, Chongqing Key Lab Hypertens Res, Chongqing, Peoples R China; [Qu, Xuemei; Chen, Ken] Fifth Peoples Hosp Chongqing, Dept Cardiol, Chongqing, Peoples R China"

通信作者："Zeng, CY (通讯作者)，ChongQing Med Univ, Chongqing, Peoples R China.; Zeng, CY (通讯作者)，Third Mil Med Univ, Army Med Univ, Daping Hosp, Dept Cardiol, Chongqing, Peoples R China.; Chen, K; Zeng, CY (通讯作者)，Univ Chinese Acad Sci, Chinese Acad Sci, Cardiovasc Res Ctr Chongqing Coll, Chongqing, Peoples R China.; Zeng, CY (通讯作者)，Chongqing Cardiovasc Clin Res Ctr Chongqing Inst C, Chongqing Key Lab Hypertens Res, Chongqing, Peoples R China.; Chen, K (通讯作者)，Fifth Peoples Hosp Chongqing, Dept Cardiol, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000901613600001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：atrial fibrillation; triglyceride-glucose index; insulin resistance; diabet mellitus type 2; arrhythmia

摘要："BackgroundInsulin resistance is associated with atrial remodeling as well as atrial fibrillation (AF). However, there was limited evidence on the relationship of triglyceride-glucose index (TyG) index, a simple, valuable marker of insulin resistance, with AF. Thus, we aimed to investigate the association between TyG index and AF among hospitalized patients. MethodsA retrospective observational study was conducted in Daping Hospital, which included 356 hospitalized patients from the Department of Cardiology. Clinical and biochemical parameters were collected from electronic medical records and AF was diagnosed from electrocardiogram (ECG) findings. ResultsWe found that the TyG index was significantly higher in the AF group than in the group without AF. Multivariate logistic regression revealed that hypertension (OR = 1.756, 95%CI 1.135-2.717, P = 0.011) and TyG index (OR = 2.092, 95%CI 1.412-3.100, P<0.001) were positively associated with AF. The analysis of the area under the ROC curve was performed and revealed that area under curve (AUC) of TyG index was 0.600 (95%CI, 0.542-0.659, P = 0.001), the optimal critical value was 8.35, the sensitivity was 65.4%, and the specificity was 52.0%. Additional subgroup analyses of diabetic and non-diabetic subjects were also performed and found the TyG index was increased in non-diabetic subjects with AF. Furthermore, a logistic regression analysis showed TyG index was associated with AF (OR = 3.065, 95% CI, 1.819-5.166, P<0.001) in non-diabetic subjects. However, TyG index was not associated with AF in diabetic subjects. ConclusionElevated TyG index is an independent risk factor for AF among non-diabetic hospitalized patients."

基金机构：Senior Medical Talents Program of Chongqing for Young [[2022]15]

基金资助正文：These studies were supported in part by grants from Senior Medical Talents Program of Chongqing for Young and Middleaged (No. [2022]15).