The initiation of oxidative stress and therapeutic strategies in wound healing

作者全名："Wang, Gang; Yang, Feifei; Zhou, Weiying; Xiao, Nanyang; Luo, Mao; Tang, Zonghao"

作者地址："[Wang, Gang; Luo, Mao; Tang, Zonghao] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Cardiovasc Pharmacol, Luzhou, Peoples R China; [Wang, Gang; Luo, Mao; Tang, Zonghao] Southwest Med Univ, Drug Discovery Res Ctr, Luzhou, Peoples R China; [Wang, Gang; Yang, Feifei; Zhou, Weiying] Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing, Peoples R China; [Wang, Gang; Zhou, Weiying] Chongqing Key Lab Drug Metab, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing, Peoples R China; [Xiao, Nanyang] Univ Chicago, Dept Microbiol, Chicago, IL USA; [Tang, Zonghao] Cedars Sinai Med Ctr, Los Angeles, CA USA"

通信作者："Luo, M; Tang, ZH (通讯作者)，Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Cardiovasc Pharmacol, Luzhou, Peoples R China."

来源：BIOMEDICINE & PHARMACOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000904450500005

JCR分区：Q1

影响因子：7.5

年份：2023

卷号：157

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Oxidative stress; Reactive oxygen species; Wound healing; Potential treatment

摘要："When the production of reactive oxygen species (ROS) is overloaded surpassing the capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage termed oxidative stress (OS). This phenomenon is ubiquitously detected in many human pathological conditions. Wound healing program implicates continuous neovascularization, cell proliferation, and wound remodeling. Increasing evidence indicates that reactive oxygen species (ROS) have profound impacts on the wound healing process through regulating a series of the physio-logical and pathological program including inflammatory response, cell proliferation, angiogenesis, granulation as well as extracellular matrix formation. In most pathological wound healing processes, excessive ROS exerts a negative role on the wound healing process. Interestingly, the moderate increase of ROS levels is beneficial in killing bacteria at the wound site, which creates a sterile niche for revascularization. In this review, we discussed the physiological rhythms of wound healing and the role of ROS in this progress, aim to explore the potential manipulation of OS as a promising therapeutic avenue."

基金机构：National Natural Science Foundation of China [81800434]; Luzhou Science and Technology Bureau Foundation [2020-JYJ-37]; Collaborative foundation of Key Lab of Ministry of Education [Key-ME-2020-006]

基金资助正文：This work was supported by the National Natural Science Foundation of China (No. 81800434). Luzhou Science and Technology Bureau Foundation (2020-JYJ-37). Collaborative foundation of Key Lab of Ministry of Education (Key-ME-2020-006).