Gender differences in the ideal cutoffs of visceral fat area for predicting MAFLD in China

作者全名："Yu, Pingping; Yang, Huachao; Qi, Xiaoya; Bai, Ruixue; Zhang, Shouqin; Gong, Jianping; Mei, Ying; Hu, Peng"

作者地址："[Yu, Pingping; Qi, Xiaoya; Bai, Ruixue; Zhang, Shouqin; Mei, Ying] Chongqing Med Univ, Affiliated Hosp 2, Dept Hlth Management, Chongqing, Peoples R China; [Yu, Pingping; Hu, Peng] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Lab Mol Biol Infect Dis,Chinese Mi, Chongqing, Peoples R China; [Yang, Huachao; Gong, Jianping] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China"

通信作者："Mei, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hlth Management, Chongqing, Peoples R China.; Hu, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Lab Mol Biol Infect Dis,Chinese Mi, Chongqing, Peoples R China."

来源：LIPIDS IN HEALTH AND DISEASE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000906216500001

JCR分区：Q2

影响因子：4.5

年份：2022

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Metabolic-associated fatty liver disease (MAFLD); Visceral fat area (VFA); Quantitative Computed Tomography (QCT)

摘要："Background: Since the discovery of metabolic-associated fatty liver disease (MAFLD) in 2020, no report on the connection between the visceral fat area (VFA) and MAFLD has been published in China, and the ideal cutoffs of VFA for predicting MAFLD has not been determined so far. Thus, the purpose of this research was to clarify the relationship between VFA and MAFLD and the ideal cutoffs of VFA to predict MAFLD in the Chinese population. Methods: Five thousand three hundred forty subjects were included in this research, with 30% randomly selected for the validation set (n = 1602) and 70% for the Training set (n = 3738). The association between VFA and MAFLD was determined by multiple logistic regression. ROC curves were used to evaluate the prediction effect of VFA on MAFLD. Results: Multiple logistic regression analysis revealed that the VFA ORs (95% CIs) were 1.25 (1.20, 1.29) for women and 1.15 (1.12, 1.17) for men. Meanwhile, the VFA quartile OR (95% CI) were 3.07 (1.64, 5.75), 7.22 (3.97, 13.14), 18.91 (10.30, 34.71) for women and 3.07 (1.64, 5.75), 7.22 (3.97, 13.14),18.91 (10.30, 34.71) for men in the Q2, Q3, and Q4 groups compared with Q1. The ROC curve showed the VFA, WC, WHR, and WHtR to predict MAFLD, the AUC value of VFA was the highest and the prediction effect was the best. The ideal cutoffs of VFA to predict MAFLD was 115.55 cm(2) for women and 178.35 cm(2) for men, and the AUC was 0.788 and 0.795, respectively. Finally, the AUC was 0.773 for women and 0.800 for men in the validation set. Conclusion: VFA was an independent predictive factor for MAFLD, and the ideal cutoff of VFA to predict MAFLD was 115.55 cm(2) in women and 178.35 cm(2) in men."

基金机构：Chongqing Talents Project [cstc2021ycjh-bgzxm0150]; Chongqing Science and Technology Commission Joint Medical Project [2021MSXM057]

基金资助正文：This work is supported by the Chongqing Talents Project [cstc2021ycjh-bgzxm0150] and the Chongqing Science and Technology Commission Joint Medical Project [2021MSXM057].