Recent progress in the biology and physiology of BMP-8a

作者全名："Tang, Jiawei; Tan, Miao; Liao, Siqi; Pang, Mengwei; Li, Jie"

作者地址："[Tang, Jiawei; Tan, Miao; Liao, Siqi; Pang, Mengwei; Li, Jie] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Li, Jie] Chongqing Med Univ, Coll Stomatol, Chongqing 400016, Peoples R China"

通信作者："Li, J (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing 400016, Peoples R China."

来源：CONNECTIVE TISSUE RESEARCH

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000906661200001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：64

期号：3

开始页：219

结束页：228

文献类型：Article

关键词：BMP-8a; BMP signaling pathway; osteoblast; reproductive system; disease

摘要："PurposeBMP-8a is a member of bone morphogenetic proteins (BMPs) and plays a regulatory role in human growth and development as a transcription regulator. This review aims to summarize the current research on the impact and mechanism of BMP-8a in female and male reproduction, formation and eruption of teeth, bone and cartilage development, tissue differentiation, disease occurrence, progression and prognosis.MethodsThe phrases ""BMP-8a,"" ""BMPs,"" ""regulator,"" ""mechanism,"" ""osteoblast,"" ""cartilage,"" ""cancer,"" ""disease,"" and ""inflammation"" were searched in the PubMed database. The abstracts were evaluated, and a series of original publications and reviews were examined.ResultsAccording to the search, BMP-8a affects the development of the uterus by inhibiting luteinization and plays an important role in late spermatogenesis. It is highly expressed in osteogenesis and differentially expressed in chondrogenesis. Furthermore, BMP-8a has a significant impact on the occurrence, development and prognosis of various diseases.ConclusionsBMP-8a regulates important factors and pathways, such as SMAD2/3 and SMAD1/5/8, to promote or inhibit the developmental processes of human reproductive organs. BMP-8a is also a member of the BMP family of proteins that regulates chondrogenesis and osteogenesis. In addition to its osteoinductive capabilities, BMP-8a is involved in the progression of diverse cancers."

基金机构：Undergraduate Scientific Research and Innovation Experiment Project in Chongqing Medical University [SRIEP202158]

基金资助正文：The work was supported by the Undergraduate Scientific Research and Innovation Experiment Project in Chongqing Medical University [SRIEP202158].