"Biomimetic, pH-Responsive Nanoplatforms for Cancer Multimodal Imaging and Photothermal Immunotherapy"

作者全名："Wan, Li; Cao, Yuting; Cheng, Chen; Tang, Rui; Wu, Nianhong; Zhou, Ying; Xiong, Xialin; He, Hongye; Lin, Xiaohong; Jiang, Qinqin; Wang, Xiaoting; Guo, Xun; Wang, Dong; Ran, Haitao; Ren, Jianli; Zhou, Yang; Hu, Zhongqian; Li, Pan"

作者地址："[Wan, Li; Cao, Yuting; Tang, Rui; Wu, Nianhong; Zhou, Ying; Xiong, Xialin; He, Hongye; Jiang, Qinqin; Wang, Xiaoting; Guo, Xun; Ran, Haitao; Ren, Jianli; Li, Pan] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Cao, Yuting; Tang, Rui; Wu, Nianhong; Zhou, Ying; Xiong, Xialin; He, Hongye; Jiang, Qinqin; Wang, Xiaoting; Guo, Xun; Ran, Haitao; Ren, Jianli; Li, Pan] Chongqing Med Univ, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China; [Wan, Li] Chongqing Med Univ, Inst Ultrasound Imaging, Hlth Management Phys Examinat Ctr, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Cheng, Chen] Chongqing Med Univ, Bishan Hosp Chongqing, Dept Ultrasound, Chongqing 400010, Peoples R China; [Lin, Xiaohong] Chongqing Gen Hosp, Dept Ultrasound, Chongqing 401147, Peoples R China; [Wang, Dong] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing 400010, Peoples R China; [Zhou, Yang] Southwest Jiaotong Univ, Peoples Hosp Chengdu City 3, Dept Ultrasound, Affiliated Hosp, Chengdu 610031, Peoples R China; [Hu, Zhongqian] Southeast Univ, Zhongda Hosp, Sch Med, Dept Ultrasound, Nanjing 210009, Jiangsu, Peoples R China"

通信作者："Li, P (通讯作者)，Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 2, Chongqing 400010, Peoples R China.; Li, P (通讯作者)，Chongqing Med Univ, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China.; Hu, ZQ (通讯作者)，Southeast Univ, Zhongda Hosp, Sch Med, Dept Ultrasound, Nanjing 210009, Jiangsu, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000907020700001

JCR分区：Q1

影响因子：9.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：photothermal treatment; multimodal imaging guidance; pH-sensitive; homologous targeting; PD-1 checkpoint blocking

摘要："Photothermal therapy (PTT), by converting light to thermal energy, has become a novel and noninvasive technique for tumor thermal ablation in clinical practice. However, as a result of phagocytosis of reticuloendothelial cells, current photothermal agents (PTAs) derived from exogenous materials suffer from incompetent tumor targeting and brief internal circulation time. The resulting poor accumulation of PTAs in the target area severely reduces the efficacy of PTT. In addition, the potential toxicity of PTAs, excessive laser exposure, and possibilities of tumor recurrence and metastasis following PTT are still intractable problems that severely influence patients' quality of life. Herein, a biomimetic pH-responsive nanoprobe was prepared via cancer cell membrane coating polydopamine (PDA)-CaCO3 nanoparticles (CPCaNPs) for photoacoustic (PA)/ultrasonic (US)/thermal imaging-guided PTT. When CPCaNPs targeted and infiltrated into the tumor's acidic microenvironment, the decomposed CO2 bubbles from homologous targeting CPCaNPs enhanced ultrasonic (US) signals obviously. At the same time, the PDA of CPCaNPs not only performed efficient PTT of primary tumors but also generated photoacoustic (PA) signals. In addition, an immune checkpoint pathway blockade was combined, which inhibited tumor recurrence and metastasis significantly and improved the immunosuppressive microenvironment after PTT to a large extent. Thus, these proposed biomimetic pH-responsive CPCaNPs provide a promising strategy for precise PTT immunotherapy under the intelligent guidance of PA/US/thermal imaging and show great potential for clinical translation."

基金机构："National Natural Science Foundation Project [81971628, 81971633, 81971636]; Senior Medical Talents Program of Chongqing for Young and Middle-aged [ZQNYXGDRCGZS2021004]; Chongqing Natural Sci-ence Foundation Project [cstc2021jcyj-msxmX0220]; Chongqing Graduate Student Research Innovation Project [CYB22201]"

基金资助正文："The authors are sincerely grateful for financial support from the National Natural Science Foundation Project (81971628, 81971633, and 81971636) . The authors also appreciate the support from the Senior Medical Talents Program of Chongqing for Young and Middle-aged (ZQNYXGDRCGZS2021004) , the Chongqing Natural Science Foundation Project (cstc2021jcyj-msxmX0220) , and the Chongqing Graduate Student Research Innovation Project (CYB22201) ."