A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression
作者全名："Chen, Siqin; Yu, Yang; Yuan, Yixiao; Chen, Xi; Zhou, Fan; Li, Yongwu; Wang, Ping; Jiang, Xiulin; Tian, Sha; Ren, Wenjun"
作者地址："[Chen, Siqin] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Oncol, Changsha 410006, Peoples R China; [Yu, Yang] Kunming Univ Sci & Technol, Affiliated Hosp, Peoples Hosp Yunnan Prov 1, Dept Thorac Surg, Kunming 650034, Yunnan, Peoples R China; [Yuan, Yixiao] Chongqing Med Univ, Affiliated Hosp 1, Key Lab Mol Oncol & Epigenet, Chongqing 400016, Peoples R China; [Chen, Xi; Zhou, Fan] Kunming Med Univ, Affiliated Hosp 2, Dept Neurosurg, Kunming 650223, Yunnan, Peoples R China; [Li, Yongwu; Ren, Wenjun] Univ Sci & Technol, Affiliated Hosp Kunming, Peoples Hosp Yunnan Prov 1, Dept Cardiothorac Surg, Kunming 650034, Yunnan, Peoples R China; [Wang, Ping; Ren, Wenjun] Kunming Med Univ, Affiliated Hosp 2, Dept Thorac Surg, Kunming, Peoples R China; [Jiang, Xiulin] Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China; [Tian, Sha] Macau Univ Sci & Technol, Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med,Dr Nehers Biophys Lab Innovat Dr, Taipa 410006, Macao, Peoples R China"
通信作者："Ren, WJ (通讯作者)，Univ Sci & Technol, Affiliated Hosp Kunming, Peoples Hosp Yunnan Prov 1, Dept Cardiothorac Surg, Kunming 650034, Yunnan, Peoples R China.; Ren, WJ (通讯作者)，Kunming Med Univ, Affiliated Hosp 2, Dept Thorac Surg, Kunming, Peoples R China.; Jiang, XL (通讯作者)，Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China.; Tian, S (通讯作者)，Macau Univ Sci & Technol, Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med,Dr Nehers Biophys Lab Innovat Dr, Taipa 410006, Macao, Peoples R China."
来源：AGING-US
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:000908367900012
JCR分区：Q2
影响因子：5.2
年份：2022
卷号：14
期号：24
开始页：9924
结束页：9941
文献类型：Article
关键词：lncRNA; lung adenocarcinoma; immune cell infiltration; prognosis biomarker; cell growth
摘要："Long noncoding RNAs (lncRNAs) reportedly play critical roles in the pathogenesis of various cancers, including lung adenocarcinoma (LUAD). However, the expression level, clinical significance, and potential function of lncRNA-AC092718.4 in LUAD remain unclear. In this study, we found that AC092718.4 was highly expressed in LUAD and high expression of AC092718.4 was correlated with poor overall survival (OS) and disease-specific survival (DSS) in LUAD. Cox regression analysis confirmed that AC092718.4 was an independent factor for LUAD prognosis. Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that AC092718.4 was involved in the PI3K-Akt signaling pathway, Th17 cell differentiation, and cell apoptosis. AC092718.4 expression was correlated with immune cell infiltration. Finally, we found that the knockdown of AC092718.4 inhibited lung adenocarcinoma (LUAD) cell growth and promote cell apoptosis. Our findings confirmed that AC092718.4 may serve as a potential prognostic biomarker in LUAD."
基金机构：Yunnan Fundamental Research Projects [202101AS070043]; Kunming Science and Technology Plan Project [2020-1-H-003]; First People's Hospital of Yunnan Province Clinical Medicine Center Opening Project [2021LCZXXF-XB3]; Chinese Medicine ScientificResearch Program of Hunan Province [2021235]; Excellent Youth Program of Hunan Provincial Education Department [21B0384]; Hunan Provincial Health Commission Project [B202319017574]; Hunan Province Natural Science Foundation [2021JJ40405]
基金资助正文："This work was supported by Yunnan Fundamental Research Projects (grant NO. 202101AS070043) , Kunming Science and Technology Plan Project (grant NO. 2020-1-H-003) . The First People's Hospital of Yunnan Province Clinical Medicine Center Opening Project (grant 2021LCZXXF-XB3. Chinese Medicine Scientific Research Program of Hunan Province (2021235) , according to Hunan Province Natural Science Foundation (2021JJ40405) , and Excellent Youth Program of Hunan Provincial Education Department (21B0384) ; Hunan Provincial Health Commission Project (B202319017574) ."
