An insight into sex-specific neurotoxicity and molecular mechanisms of DEHP: A critical review
作者全名："Liu, Yiyun; Guo, Zhiling; Zhu, Ruihong; Gou, Dongzhi; Jia, Pan-Pan; Pei, De-Sheng"
作者地址："[Liu, Yiyun; Gou, Dongzhi; Jia, Pan-Pan; Pei, De-Sheng] Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China; [Guo, Zhiling] Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham B15 2TT, England; [Zhu, Ruihong] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China"
通信作者："Pei, DS (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China."
关键词：DEHP; Neurotoxicity; Nerve cell damage; Sex -specific
摘要："Di-2-Ethylhexyl Phthalate (DEHP) is often used as an additive in polyvinyl chloride (PVC) to give plastics flexibility, which makes DEHP widely used in food packaging, daily necessities, medical equipment, and other products. However, due to the unstable combination of DEHP and polymer, it will migrate to the environment in the materials and eventually contact the human body. It has been recorded that low-dose DEHP will increase neurotoxicity in the nervous system, and the human health effects of DEHP have been paid attention to because of the extensive exposure to DEHP and its high absorption during brain development. In this study, we review the evidence that DEHP exposure is associated with neurodevelopmental abnormalities and neurological diseases based on human epidemiological and animal behavioral studies. Besides, we also summarized the oxidative damage, apoptosis, and signal transduction disorder related to neurobehavioral abnormalities and nerve injury, and described the potential mechanisms of neurotoxicity caused by DEHP. Overall, we found exposure to DEHP during the critical developmental period will increase the risk of neurobehavioral abnormalities, depression, and autism spectrum disorders. This effect is sex-specific and will continue to adulthood and even have an inter -generational effect. However, the research results on the sex-dependence of DEHP neurotoxicity are inconsistent, and there is a lack of systematic mechanisms research as theoretical support. Future investigations need to be carried out in a large-scale population and model organisms to produce more consistent and convincing results. And we emphasize the importance of mechanism research, which can enhance the understanding of the envi-ronmental and human health risks of DEHP exposure."
基金机构："High-level Talents Project of Chongqing Medical University, China [R4014, R4021, R4020, R4015]; Chongqing Postdoctoral Science Foundation [2022TQ0394, cstc2022]; Research Program of Chongqing Science and Technology Commission [cstc2019jcyj-zdxmX0035, CSTCCXLJRC201714]; China-Sri Lanka Joint Research and Demonstration Center for Water Technology, China-Sri Lanka Joint Center for Education and Research, Chinese Academy of Sciences, China"
基金资助正文："This work was supported by the High-level Talents Project of Chongqing Medical University (No. R4014, R4021, R4020, and R4015), China and Chongqing Postdoctoral Science Foundation (2022TQ0394 and cstc2022), Research Program of Chongqing Science and Technology Commission (No. cstc2019jcyj-zdxmX0035 and CSTCCXLJRC201714), and China-Sri Lanka Joint Research and Demonstration Center for Water Technology, China-Sri Lanka Joint Center for Education and Research, Chinese Academy of Sciences, China"