Photochemically-driven highly efficient intracellular delivery and light/hypoxia programmable triggered cancer photo-chemotherapy

作者全名:"Zhang, Wei; Zhang, Cuncheng; Yang, Chao; Wang, Xingyue; Liu, Weiwei; Yang, Mi; Cao, Yang; Ran, Haitao"

作者地址:"[Zhang, Wei; Wang, Xingyue; Liu, Weiwei; Yang, Mi; Cao, Yang; Ran, Haitao] Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [Zhang, Wei; Wang, Xingyue; Liu, Weiwei; Yang, Mi; Cao, Yang; Ran, Haitao] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [Zhang, Cuncheng] Chongqing Gen Hosp, Dept Ultrasound, 104 Pipashan Main St, Chongqing 40013, Peoples R China; [Yang, Chao] Chongqing Gen Hosp, Dept Radiol, 104 Pipashan Main St, Chongqing 40013, Peoples R China"

通信作者:"Ran, HT (通讯作者),Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China.; Ran, HT (通讯作者),Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源:JOURNAL OF NANOBIOTECHNOLOGY

ESI学科分类:BIOLOGY & BIOCHEMISTRY

WOS号:WOS:000912432400001

JCR分区:Q1

影响因子:10.2

年份:2023

卷号:21

期号:1

开始页: 

结束页: 

文献类型:Article

关键词:Porphyrinic metal organic framework; Stimuli-responsive; Hypoxia; Nanomedicine; Photochemotherapy

摘要:"Background Using nanotechnology to improve the efficiency of tumor treatment represents a major research interest in recent years. However, there are paradoxes and obstacles in using a single nanoparticle to fulfill all the requirements of complex tumor treatment.Results In this paper, a programmed-triggered nanoplatform (APP NPs), which is sequentially responsive to light and hypoxia, is rationally integrated for photoacoustic (PA) imaging-guided synergistic cancer photo-chemotherapy. The nanoplatform is constructed by in situ hybridization of dopamine monomer in the skeleton of PCN-224 and loading prodrug banoxantrone (AQ4N). Upon first-stage irradiation with a 660 nm laser, cellular internalization was effectively promoted by a photosensitizer-mediated photochemical effect. Furthermore, under second-stage irradiation, APP NPs exhibit a notably high photothermal conversion efficiency and sufficient reactive oxygen species (ROS) production for photothermal therapy (PTT) and photodynamic therapy (PDT), respectively, which not only triggers rapid intercellular drug release but also consequently aggravates tumor hypoxia levels, and aggravated hypoxia can further active the cytotoxicity of AQ4N for chemotherapy. Both in vitro and in vivo studies confirm that the dual-stage light guided photo-chemotherapy strategy exhibits a greatly enhanced anticancer effects and superior therapeutic safety.Conclusion This work represents a versatile strategy to construct a dual-stage light induced PDT/PTT and hypoxia-activated chemotherapy nanoplatform and will be promising for the development of multistimuli-responsive nanosystems with programmable functions for precise cancer therapy."

基金机构:"National Natural Science Foundation of China [81630047, 82071926]; the Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-K202000402]"

基金资助正文:"This work was supported by the National Natural Science Foundation of China (81630047, 82071926), the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJZD-K202000402)."