A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection

作者全名："Zhang, Qi; Liu, Zehan; Liu, Shuangqing; Wang, Ming; Li, Xinye; Xun, Jing; Wang, Xiangyu; Yang, Qin; Wang, Ximo; Zhang, Dapeng"

作者地址："[Zhang, Qi; Liu, Zehan; Liu, Shuangqing; Xun, Jing; Zhang, Dapeng] Tianjin Med Univ, Tianjin Nankai Hosp, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin, Peoples R China; [Zhang, Qi; Xun, Jing; Zhang, Dapeng] Tianjin Univ, Integrated Chinese & Western Med Hosp, Tianjin, Peoples R China; [Liu, Zehan; Wang, Ming; Yang, Qin] Chongqing Med Univ, Affiliated Hosp Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Dept Gen Surg, Chengdu, Peoples R China; [Liu, Zehan; Wang, Ming; Yang, Qin] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu, Peoples R China; [Li, Xinye] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Thorac Surg, Hangzhou, Peoples R China; [Wang, Xiangyu; Wang, Ximo] Tianjin Univ, Acad Med Engn & Translat Med, Tianjin, Peoples R China"

通信作者："Zhang, DP (通讯作者)，Tianjin Med Univ, Tianjin Nankai Hosp, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin, Peoples R China.; Zhang, DP (通讯作者)，Tianjin Univ, Integrated Chinese & Western Med Hosp, Tianjin, Peoples R China.; Wang, XM (通讯作者)，Tianjin Univ, Acad Med Engn & Translat Med, Tianjin, Peoples R China."

来源：FRONTIERS IN SURGERY

ESI学科分类：　

WOS号：WOS:000913800200001

JCR分区：Q2

影响因子：1.8

年份：2023

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：perihilar cholangiocarcinoma; nomogram; overall survival; lymph node dissection; SEER

摘要："ObjectiveTo construct a reliable nomogram available online to predict the postoperative survival of patients with perihilar cholangiocarcinoma. MethodsData from 1808 patients diagnosed with perihilar cholangiocarcinoma between 2004 and 2015 were extracted from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database. They were randomly divided into training and validation sets. The nomogram was established by machine learning and Cox model. The discriminant ability and prediction accuracy of the nomogram were evaluated by concordance index (C-index), receiver operator characteristic (ROC) curve and calibration curve. Kaplan-Meier curves show the prognostic value of the associated risk factors and classification system. ResultsMachine learning and multivariate Cox risk regression model showed that sex, age, tumor differentiation, primary tumor stage(T), lymph node metastasis(N), TNM stage, surgery, radiation, chemotherapy, lymph node dissection were associated with the prognosis of perihilar cholangiocarcinoma patients relevant factors (P < 0.05). A novel nomogram was established. The calibration plots, C-index and ROC curve for predictions of the 1-, 3-, and 5-year OS were in excellent agreement. In patients with stage T1 and N0 perihilar cholangiocarcinoma, the prognosis of >= 4 lymph nodes dissected was better than that of 1- 3 lymph nodes dissected (P < 0.01). ConclusionThe nomogram prognostic prediction model can provide a reference for evaluating the prognosis and survival rate of patients with perihilar cholangiocarcinoma. Patients with stage T1 and N0 perihilar cholangiocarcinoma have more benefits by increasing the number of lymph node dissection."

基金机构：　

基金资助正文：