Preoperative prediction of early recurrence of HBV-related hepatocellular carcinoma (<= 5 cm) by visceral adipose tissue index

作者全名："Wu, Zong-qian; Cheng, Jie; Xiao, Xi-xi; Zhang, Hua-rong; Wang, Jian; Peng, Juan; Liu, Chen; Cai, Ping; Li, Xiao-ming"

作者地址："[Wu, Zong-qian; Cheng, Jie; Wang, Jian; Liu, Chen; Cai, Ping; Li, Xiao-ming] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Dept Radiol, Chongqing, Peoples R China; [Xiao, Xi-xi] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Chongqing, Peoples R China; [Xiao, Xi-xi; Zhang, Hua-rong] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Southwest Canc Ctr, Chongqing, Peoples R China; [Zhang, Hua-rong] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Inst Pathol, Chongqing, Peoples R China; [Peng, Juan] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China"

通信作者："Cai, P; Li, XM (通讯作者)，Army Med Univ, Mil Med Univ 3, Southwest Hosp, Dept Radiol, Chongqing, Peoples R China."

来源：FRONTIERS IN SURGERY

ESI学科分类：　

WOS号：WOS:000913914600001

JCR分区：Q2

影响因子：1.8

年份：2023

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：visceral adipose tissue; HBV; HCC; early recurrence; abdominal adipose tissue; computed tomography

摘要："BackgroundThis study aimed to investigate whether visceral adipose tissue index (VATI) is a significant risk factor for the early recurrence (ER) of HBV-related hepatocellular carcinoma (HCC) (<= 5 cm) after hepatectomy. MethodsThe recruited cohort patients who were positive for hepatitis B virus, presented with surgically confirmed HCC (<= 5 cm) from Army Medical University (internal training cohort: n = 192) and Chongqing Medical University (external validation group: n = 46). We measured VATI, subcutaneous adipose tissue index (SATI) via computed tomography (CT). ER was defined as recurrence within 2 years after hepatectomy. The impact of parameters on outcome after hepatectomy for HCC was analyzed. ResultsUnivariate analysis showed that alpha-fetoprotein levels (p = 0.044), body mass index (BMI) (p < 0.001), SATI (p < 0.001), and VATI (p < 0.001) were significantly different between ER and non-ER groups in internal training cohort. Multivariate analysis identified VATI as an independent risk factor for ER (odds ratio = 1.07, 95% confidence interval: 1.047-1.094, p < 0.001), with a AUC of 0.802, based on the cut-off value of VATI, which was divided into high risk (>= 37.45 cm(2)/m(2)) and low risk (<37.45 cm(2)/m(2)) groups. The prognosis of low risk group was significantly higher than that of high risk group (p < 0.001). The AUC value of VATI in external validation group was 0.854. ConclusionVATI was an independent risk factor for the ER, and higher VATI was closely related to poor outcomes after hepatectomy for HBV-related HCC (<= 5 cm)."

基金机构：Program of National Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX1371]

基金资助正文："Funding The authors would like to thank the X-ML, Program of National Natural Science Foundation of Chongqing (No. CSTB2022NSCQ-MSX1371)."