Intrafollicular fluid metabolic abnormalities in relation to ovarian hyperstimulation syndrome: Follicular fluid metabolomics via gas chromatography-mass spectrometry
作者全名："Sun, Yixuan; Hao, Lijuan; Han, Wei; Luo, Jing; Zheng, Jing; Yuan, Dong; Ye, Hong; Li, Qinke; Huang, Guoning; Han, Tingli; Yang, Zhu"
作者地址："[Sun, Yixuan; Zheng, Jing; Yuan, Dong; Li, Qinke; Han, Tingli; Yang, Zhu] Chongqing Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Sun, Yixuan; Hao, Lijuan] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Han, Wei; Ye, Hong; Huang, Guoning] Chongqing Med Univ, Reprod & Genet Inst, Ctr Reprod Med, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Luo, Jing] Chongqing Med Univ, Dept Pathol, Basic Med Coll, Chongqing 400016, Peoples R China; [Huang, Guoning; Han, Tingli; Yang, Zhu] Chongqing Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China"
通信作者："Huang, GN; Han, TL; Yang, Z (通讯作者)，Chongqing Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China."
来源：CLINICA CHIMICA ACTA
关键词：Ovarian hyperstimulation syndrome; Polycystic ovarian syndrome; Follicular fluid; Metabolomics; Unsaturated fatty acids
摘要："Introduction: Ovarian hyperstimulation syndrome (OHSS) is the most serious iatrogenic complication of ovulation stimulation during assisted reproductive technology. The main objective of this study was to investigate intrafollicular fluid metabolic change profiles of OHSS in non-ovarian etiologic infertility women (CON) and poly cystic ovarian syndrome patients (PCOS).Methods: 87 infertile women were divided into four subgroups: CON-Norm (CON with normal ovarian response), CON-OHSS (CON with OHSS), PCOS-Norm (PCOS with normal ovarian response), and PCOS-OHSS (PCOS with OHSS). The intrafollicular fluid metabolic profiles were analyzed with gas chromatography-mass spectrometry. The multivariable-adjusted conditional logistic regression was applied to assess the association of metabolites with OHSS risk.Results: We identified 17 and 3 metabolites that related to OHSS risk in CON and PCOS, respectively. 13 OHSS risk-related metabolites in CON were unsaturated fatty acids, 8 of which were also the significantly altered metabolites between all PCOS and CON-Norm.Conclusion: Our study may shed light on the role of intrafollicular fluid metabolic abnormalities in the pathophysiology of OHSS. The findings suggested that there might be some metabolic heterogeneities underlying the development of OHSS in CON and PCOS women and indicated possible shared etiological factors in the development of PCOS and OHSS."
基金机构：Chongqing Natural Science Foun-dation (China) [cstc2018jcyjAX0648]; Chongqing Science and Health Joint Project [2022ZDXM009]
基金资助正文：Funding This research was supported by Chongqing Natural Science Foun-dation (China cstc2018jcyjAX0648) and Chongqing Science and Health Joint Project (2022ZDXM009) .