A Diagnostic and Therapeutic Hydrogel to Promote Vascularization via Blood Sugar Reduction for Wound Healing

作者全名："Han, Xiaoyu; Chen, Shuyu; Cai, Zhengwei; Zhu, Ying; Yi, Weiwei; Guan, Mengtong; Liao, Bo; Zhang, Ying; Shen, Jieliang; Cui, Wenguo; Bai, Dingqun"

作者地址："[Han, Xiaoyu; Chen, Shuyu; Zhu, Ying; Yi, Weiwei; Guan, Mengtong; Liao, Bo; Zhang, Ying; Bai, Dingqun] Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Cai, Zhengwei; Cui, Wenguo] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Shanghai Key Lab Prevent & Treatmen, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China; [Shen, Jieliang] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China"

通信作者："Bai, DQ (通讯作者)，Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Shanghai Key Lab Prevent & Treatmen, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China.; Shen, JL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China."

来源：ADVANCED FUNCTIONAL MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000915647500001

JCR分区：Q1

影响因子：19

年份：2023

卷号：33

期号：14

开始页：　

结束页：　

文献类型：Article

关键词：diagnosis; therapy; ultrasound; vascularization; wound healing

摘要："Chronic hyperglycemic damage is a major problem that undermines diabetic wound healing. By combining treatment and diagnosis together, blood glucose concentration can be monitored real-time through medical imaging devices and precise interventions can be carried out at the right time to promote diabetic wound repair. In this study, an injectable self-healing hyaluronic acid hydrogel is constructed using Schiff base reaction, and nanoenzymes (GOx-MnO2) synthesized by condensation reaction, along with vascular endothelial growth factor (VEGF)-nanobubbles produced by double emulsification method, are loaded into the hydrogel, thus constructing an innovative diagnostic and therapeutic hydrogel system (US@GOx@VEGF hydrogel, UGV hydrogel). While monitoring glucose concentration in real-time, the system delivers VEGF through ultrasound in a precise and noninvasive way to deplete glucose. The UGV hydrogel integrates both processes of diagnosis and treatment, effectively releases VEGF through blasts triggered by ultrasound. Apart from this, this new trauma patch is capable of monitoring Mn2+ values ranging from 0.5 m to 7.8 x 10(-3) m and glucose levels from 100 x 10(-3) to 3 x 10(-3) m, through magnetic resonance imaging. In summary, the hydrogel realizes real-time monitoring of glucose level, maintains glucose homeostasis through noninvasive intervention, and rapidly promotes the repair of diabetic skin defects, opening up a new path for chronic wound management."

基金机构："National Key Research and Development Program of China [2020YFC2005900]; National Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0792]; National Natural Science Foundation of China [82172533, 82002402, 32101104]; Chongqing Municipal Education Commission, Innovative Research Group of Universities in Chongqing [CXQT21018]; State Key Laboratory of Ultrasound Engineering in Medicine and Engineering [2020KFA3019]; Shanghai Municipal Health Planning Commission [202140127]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0076]"

基金资助正文："X.H. and S.C. contributed equally to this work. This work was supported in part by the National Key Research and Development Program of China (2020YFC2005900), the National Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0792), National Natural Science Foundation of China (82172533, 82002402, and 32101104), Chongqing Municipal Education Commission, Innovative Research Group of Universities in Chongqing (CXQT21018), State Key Laboratory of Ultrasound Engineering in Medicine and Engineering (2020KFA3019), Shanghai Municipal Health Planning Commission (202140127), and Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0076)."