"Pre-pregnancy BMI was associated with gestational depressive phenotypes in a population of 12,099 women in Chongqing, China"

作者全名："Chen, Yi; Gu, Huayan; Zhou, Niya; Zhou, Wenzheng; Cao, Jia; Chen, Qing; Zhang, Haiyan"

作者地址："[Chen, Yi; Cao, Jia; Chen, Qing] Army Med Univ, Mil Med Univ 3, Inst Toxicol, Coll Prevent Med, Chongqing, Peoples R China; [Chen, Yi] Guizhou Med Univ, Sch Publ Hlth, Guiyang, Peoples R China; [Gu, Huayan; Zhang, Haiyan] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Zhou, Niya] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Clin Res Ctr, Chongqing, Peoples R China; [Zhou, Wenzheng] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Qual Management, Chongqing, Peoples R China"

通信作者："Chen, Q (通讯作者)，Army Med Univ, Mil Med Univ 3, Inst Toxicol, Coll Prevent Med, Chongqing, Peoples R China.; Zhang, HY (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000917588300001

JCR分区：Q2

影响因子：5.2

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：BMI; gestational depression; depressive phenotypes; pregnancy; obesity

摘要："ObjectiveTo investigate the association between pre-pregnancy body mass index (BMI) and gestational depressive phenotypes. MethodsThe pregnant women receiving the first prenatal examination (4th -13th week of gestation) in Chongqing Health Center for Women and Children were recruited between February 2020 and September 2021. Depressive phenotypes was assessed by the Patient Health Questionnaire (PHQ-9) and the Symptom Checklist 90 (SCL-90) scale at recruitment. Pre-pregnancy weight and height were self-reported by the participants. Demographic and obstetric characteristics were obtained from the hospital information system. The association between pre-pregnancy BMI and the scores of PHQ-9 or SCL-90 scale was investigated by uni-variate analysis with Kruskal-Wallis test and by multi-variate analysis with linear regression model with adjustment of age, parity, smoking, alcohol consumption, and assisted reproduction. The association between pre-pregnancy BMI and PHQ-9 or SCL-90 diagnosed depressive phenotypes was analyzed by Chi-square test and logistic regression respectively. ResultsA total of 12,099 pregnant women were included, where 100% of them filled out the PHQ-9 scale and 99.6% filled out the SCL-90 scale, and 47.26% and 4.62% of the pregnant women had depressive phenotypes, respectively. Women with higher pre-pregnancy BMI had lower depressive phenotypes scores during pregnancy. Multivariable analysis of the PHQ-9 scale showed that overweight/obese subjects had a higher incidence of depressive phenotypes compared with subjects with normal BMI (OR=0.803, 95% CI [0.723, 0.892]). In a stratified analysis assessed by the PHQ-9, women who were overweight/obese prior to pregnancy were less likely to develop depressive phenotypes during pregnancy than women who were normal weight prior to pregnancy, regardless of whether they were nulliparous (OR=0.795, 95%CI[0.696,0.908]) or multiparous (OR=0.809, 95%CI[0.0.681,0.962]), while in the three age groups of 25-29 years, 30-34 years and >= 35 years, pre-pregnancy overweight/obesity were associated with lower risk of gestational depressive phenotypes. However, analysis of the SCL-90 scale showed no statistical association between depressive symptom and BMI. No substantial interaction was observed between BMI and parity or age. ConclusionsIncreased pre-pregnancy BMI may be associated with reduced risk of gestational depressive phenotypes in Chinese women. Independent studies are warranted to validate the findings of the present study."

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