The role of Hippo pathway in ferroptosis
作者全名："Xiang, Jiangxia; Jiang, Mengmeng; Du, Xing"
作者地址："[Xiang, Jiangxia] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Traumatol, Chongqing, Peoples R China; [Jiang, Mengmeng] Third Cent Hosp Tianjin, Dept Med Oncol, Tianjin, Peoples R China; [Du, Xing] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China; [Du, Xing] Orthoped Lab Chongqing Med Univ, Chongqing, Peoples R China"
通信作者："Du, X (通讯作者)，Orthoped Lab Chongqing Med Univ, Chongqing, Peoples R China."
来源：FRONTIERS IN ONCOLOGY
关键词：Hippo pathway; YAP; ferroptosis; iron metabolism; ROS
摘要："The role of Hippo pathway in ferroptosisThe Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors."
基金机构："Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0972, cstc2020jcyj-msxmX0541]; Basic Research and Frontier Exploration Project of Yuzhong District of Chongqing ; Natural Science Foundation of Tianjin [20JCQNJC01400]"
基金资助正文："Funding This work was funded by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0972, cstc2020jcyj-msxmX0541), the Basic Research and Frontier Exploration Project of Yuzhong District of Chongqing (20200142), and the Natural Science Foundation of Tianjin (20JCQNJC01400)."