Supramolecular Room-Temperature Phosphorescent Hydrogel Based on Hexamethyl Cucurbit[5]uril for Cell Imaging

作者全名："Sun, Xi-Ran; Yang, Hai-Ping; Zhang, Wei; Zhang, Shuai; Hu, Jian-Hang; Liu, Ming; Zeng, Xi; Li, Qiu; Redshaw, Carl; Tao, Zhu; Xiao, Xin"

作者地址："[Sun, Xi-Ran; Zhang, Wei; Zhang, Shuai; Hu, Jian-Hang; Liu, Ming; Zeng, Xi; Tao, Zhu; Xiao, Xin] Guizhou Univ, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Appl Chem, Guiyang 550025, Peoples R China; [Yang, Hai-Ping; Li, Qiu] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Nephrol,Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China; [Redshaw, Carl] Univ Hull, Sch Nat Sci, Chem, Kingston Upon Hull HU6 7RX, England"

通信作者："Zeng, X; Xiao, X (通讯作者)，Guizhou Univ, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Appl Chem, Guiyang 550025, Peoples R China.; Li, Q (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Nephrol,Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000918287700001

JCR分区：Q1

影响因子：9.5

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：cucurbit[n]urils; self-assembly; supramolecular hydrogel; cell imaging

摘要："The host-guest interaction between hexamethyl cucurbit[5]uril (HmeQ[5]) and 1,4-diaminobenzene (DB) was investigated, and a new low-molecular-weight supramolecular gel was prepared by a simple heating/mixing cooling method. The structure and properties of the supramolecular gel were characterized. Results revealed that DB molecules did not enter the cavity of HmeQ[5] and that hydrogen bonding between the carbonyl group at the HmeQ[5] port and the DB amino groups, together with dipole-dipole interactions and outer wall interactions, were the main driving forces for the formation of the supramolecular gel. The HmeQ[5]/DB gel system exhibits temperature sensitivity. The phosphor 6-bromo-2-naphthol (BrNp) was embedded in the gel to give the gel fluorescent phosphorescence double emission. The double emission ability at room temperature can be attributed to the ordered microstructure of the supramolecular gel, which effectively avoids the nonradiative transition of BrNp. Meanwhile, HmeQ[5]/DB-BrNp has good biocompatibility and low biotoxicity, which is compatible with HeLa cells to achieve cytoplasmic staining of HeLa in the red channel. The supramolecular gels constructed by this supramolecular assembly strategy not only have good temperature sensitivity but also extend the application of Q[n]s in biomedical fields."

基金机构：National Natural Science Foundation of China [21861011]; Science and Technology Fund of Guizhou Province [2018-5781]; University of Hull

基金资助正文：ACKNOWLEDGMENTS This work was financially supported by the National Natural Science Foundation of China (No. 21861011) and the Science and Technology Fund of Guizhou Province (No. 2018-5781) . CR thanks the University of Hull for its support.