Use of NHFOV vs. NIPPV for the respiratory support of preterm newborns after extubation: A meta-analysis

作者全名："Mei, Zhaojun; Ming, Li; Wu, Zhifeng; Zhu, Yong"

作者地址："[Mei, Zhaojun] Luzhou Second Peoples Hosp, Luzhou Maternal & Child Hlth Hosp, Luzhou, Peoples R China; [Ming, Li; Wu, Zhifeng] Army Med Univ, Xinqiao Hosp, Dept Pediat, Chongqing, Peoples R China; [Zhu, Yong] Chongqing Med Univ, Univ Town Hosp, Dept Pediat Ctr, Chongqing, Peoples R China"

通信作者："Wu, ZF (通讯作者)，Army Med Univ, Xinqiao Hosp, Dept Pediat, Chongqing, Peoples R China.; Zhu, Y (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Dept Pediat Ctr, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000922262400001

JCR分区：Q1

影响因子：2.6

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：noninvasive high-frequency oscillatory ventilation; nasal intermittent positive-pressure ventilation; preterm infants; respiratory support; meta-analysis

摘要："ObjectivesThis meta-analysis evaluated and compared the efficacy and safety of noninvasive high-frequency oscillatory ventilation (NHFOV) and nasal intermittent positive-pressure ventilation (NIPPV) for preterm newborns after extubation. MethodsWe searched the PubMed, Cochrane Library, EMBASE, Web of Science, CNKI, Wanfang and VIP databases from inception to August 28, 2022. Randomized controlled trials (RCTs) that evaluated and compared the efficacy and safety of NHFOV and NIPPV in newborns were included in the review and meta-analysis, which followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. ResultsEight studies involving 1,603 patients were included. Compared with NIPPV, NHFOV could reduce the reintubation rates (RR = 0.68, 95% CI 0.53, 0.86, P = 0.002). Subgroup analysis showed that the significant difference was found in reintubation rates within 72 h (RR = 0.48, 95% CI 0.32, 0.73, P = 0.0005). NHFOV also could decrease the duration of non-invasive ventilation (standard mean difference (SMD) = -1.52, 95% CI -2.58, -0.45, P = 0.005). However, all included studies had a high risk of bias, and the overall quality of the evidence of the outcomes was low or very low. ConclusionIn our study, compared with NIPPV, NHFOV seems to reduce the reintubation rates without increasing adverse outcomes. Nevertheless, definite recommendations cannot be made based on the quality of the published evidence."

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