Three-dimensional pseudocontinuous arterial spin labeling perfusion imaging shows cerebral blood flow perfusion decline in attention-deficit/hyperactivity disorder children

作者全名："Tang, Shilong; Liu, Xianfan; Nie, Lisha; Qian, Fangfang; Chen, Wushang; He, Ling"

作者地址："[Tang, Shilong; Liu, Xianfan; Qian, Fangfang; Chen, Wushang; He, Ling] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol, Minist Educ Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; [Nie, Lisha] GE Healthcare, MR Res China, Beijing, Peoples R China"

通信作者："He, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol, Minist Educ Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000922545600001

JCR分区：Q2

影响因子：4.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：children; attention-deficit; hyperactivity disorder; magnetic resonance imaging; brain; 3D-pcASL

摘要："PurposeTo investigate the feasibility of three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL) perfusion imaging in the brain of children with Attention-deficit/hyperactivity disorder (ADHD). MethodsA total of 78 ADHD children aged 5-13 years were prospectively selected as the study group, and 89 healthy children matched in age and sex were selected as the control group. All children underwent MRI conventional sequence, 3D-pcASL, and 3D-T1 sequence scans. The brain gray and white matter volume and cerebral blood flow (CBF) perfusion values were obtained by software post-processing, and were compared and analyzed in the two groups to find out their characteristics in the brain of ADHD children. ResultsThe total brain volume and total CBF values were lower in ADHD children than in healthy children (P < 0.05); the gray and white matter volumes in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus and other brain regions were lower in ADHD children than in healthy children (P < 0.05); the gray matter CBF values in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus and other brain regions were lower in ADHD children than in healthy children (P < 0.05); the differences between the white matter CBF values of white matter in the said brain regions of ADHD children and healthy children were not statistically significant (P > 0.05); and the CBF values in frontal lobe and caudate nuclei could distinguish ADHD children (AUC > 0.05, P < 0.05). ConclusionThe 3D-pcASL technique showed reduced cerebral perfusion in some brain regions of ADHD children."

基金机构："National Clinical Research Center for Child Health and Disorders (Children's Hospital of Chongqing Medical University, Chongqing, China) [NCRCCHD-2021-YP-07]; Chongqing Municipal Education Commission [KJQN202000425]"

基金资助正文："This study protocol was supported by grants from National Clinical Research Center for Child Health and Disorders (Children's Hospital of Chongqing Medical University, Chongqing, China) (grant number NCRCCHD-2021-YP-07) and Chongqing Municipal Education Commission (No. KJQN202000425)."