LAMC2 as a prognostic biomarker in human cancer: a systematic review and meta-analysis

作者全名："Fu, Tao; Liu, Jun-Xia; Xie, Juan; Gao, Zhen; Yang, Zhenshan"

作者地址："[Fu, Tao; Liu, Jun-Xia; Xie, Juan] Chongqing Hlth Ctr Women & Children, Chongqing Clin Res Ctr Reprod Med, Chongqing, Peoples R China; [Fu, Tao; Liu, Jun-Xia; Xie, Juan] Chongqing Med Univ, Women & Childrens Hosp, Ctr Reprod Med, Chongqing Key Lab Human Engn, Chongqing, Peoples R China; [Gao, Zhen] Northwest A&F Univ, Coll Anim Vet Med, Yangling, Shaanxi, Peoples R China; [Yang, Zhenshan] South China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China"

通信作者："Yang, ZS (通讯作者)，South China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China."

来源：BMJ OPEN

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000924531200012

JCR分区：Q1

影响因子：2.9

年份：2022

卷号：12

期号：11

开始页：　

结束页：　

文献类型：Review

关键词：ONCOLOGY; Adult oncology; Oncogenes

摘要："ObjectivesAccumulating evidence suggested that the laminin gamma 2 (LAMC2) expression level was upregulated in various cancers. However, the potential prognostic value of LAMC2 in cancers remains unclear. We conducted a meta-analysis to clarify the association of LAMC2 expression with prognosis. DesignWe searched Embase, Web of Science and PubMed (up to 25 November 2021) to collect all eligible studies, and meta-analysis was performed to interpret the association of LAMC2 expression with clinicopathological parameters, overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS). Eligibility criteria for including studiesWe included studies that investigate the relationship between LAMC2 and prognosis of cancers, patients were divided into two groups, and associations of LAMC2 expression with clinicopathological features were described. ResultsSeven studies were finally included. We found that increased LAMC2 expression was significantly associated with lymph node metastasis (log OR 0.88, 95% CI 0.38 to 1.38, p<0.001), tumour-node-metastasis stages (log OR: 0.95, 95%CI 0.39 to 1.50, p<0.001) and tumour status (log OR 1.26, 95%CI 0.84 to 1.68, p<0.001), but not with age (log OR -0.05, 95%CI -0.37 to 0.27, p=0.75) or gender (log OR -0.07, 95%CI -0.52 to 0.38, p=0.75). In addition, higher LAMC2 expression was found to be significantly associated with OS/PFS/DSS (HR 1.85, 95%CI 1.31 to 2.40, p<0.001). A similar result was found in The Cancer Genome Atlas database. High LAMC2 expression was significantly associated with OS in lung adenocarcinoma, mesothelioma, skin cutaneous melanoma, neck squamous cell carcinoma and brain lower grade glioma. ConclusionOur results suggested that higher LAMC2 expression was correlated with worse survival, lymph node metastasis, tumour-node-metastasis stages and tumour status. This study was subject to inherent limitations, but the results presented here provide insights regarding the potential use of LAMC2 as a biomarker for human cancer. Study registrationresearchregistry.com (researchregistry1319)."

基金机构：Chongqing Science and Health Joint Project [2021MSXM108]

基金资助正文：This study was supported by the Chongqing Science and Health Joint Project (2021MSXM108).