Accurate Identification and Virulence Detection of Aeromonas: a Single-Center Retrospective Study on the Clinical Features and Outcomes Associated with Aeromonas Bacteremia in Southwestern China

作者全名:"Zhang, Daiqin; Li, Wenting; Hu, Xin; Huang, Hongyu; Zhang, Xiaobing"

作者地址:"[Zhang, Daiqin; Li, Wenting; Hu, Xin; Huang, Hongyu; Zhang, Xiaobing] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者:"Zhang, XB (通讯作者),Chongqing Med Univ, Dept Clin Lab, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源:JAPANESE JOURNAL OF INFECTIOUS DISEASES

ESI学科分类:IMMUNOLOGY

WOS号:WOS:000926232200002

JCR分区:Q4

影响因子:1.3

年份:2023

卷号:76

期号:1

开始页:7

结束页:13

文献类型:Article

关键词: 

摘要:"In this study, Aeromonas spp. were re-identified, and the clinical aspects associated with Aeromonas bacteremia, as well as thug resistance and virulence genes, were elucidated. A total of 188 isolates were classified into 7 Aeromonas spp. using housekeeping gene sequencing, which was the standard to assess the accuracy of the VITEK MALDI-TOF system and the VITEK2 Compact system. The VITEK MS system and housekeeping gene sequencing had a 39.89% clear coincidence rate, whereas the VITEK2 Compact system and the standard had a 2.13% coincidence rate. Aeromonas bacteremia was associated with septic shock, hematologic malignancy, and post-hepatitic cirrhosis. Hematological malignancy, hypoproteinemia, systemic steroid use, central venous catheterization, and virulence genes act and ast were linked to poor outcomes. Aeromonas bacteremia had a 37.5% mortality rate; however, differences in mortality rates among Aeromonas spp. were observed. According to the broth microdilution method, over 90% of isolates were sensitive to most antimicrobials, except ceftriaxone (83.33%) and imipenem (83.33%). Polymerase chain reaction and DNA sequencing verified the presence of drug resistance genes; bla(CPhA) was detected in 3 isolates, while bla(NDM-1) was found in one isolate. In summary, common methods for identifying Aeromonas spp. are ineffective. Immunocompromised patients have a higher risk of infection and mortality. Furthermore, carbapenem resistance is a serious problem."

基金机构:"Natural Science Foundation of Chongqing, China [cstc2019j-cyjmsxmX0253]"

基金资助正文:"This study was supported by the Natural Science Foundation of Chongqing, China (No. cstc2019j-cyjmsxmX0253)."