Attributes underlying patient choice of treatment modality for low-grade squamous intraepithelial lesion complicated by high-risk human papillomavirus infection
作者全名："He, Miaomiao; Jia, Ru; Liu, Xinglin; Su, Chang; Qin, Yi; Li, Chengzhi; Jia, Ying"
作者地址："[He, Miaomiao; Jia, Ru; Liu, Xinglin; Su, Chang; Qin, Yi; Li, Chengzhi; Jia, Ying] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China; [Li, Chengzhi] Chongqing Haifu Hosp, Chongqing, Peoples R China; [Jia, Ying] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Chengzhi] Chongqing Med Univ, Chongqing Haifu Hosp, Coll Biomed Engn, Chongqing, Peoples R China"
通信作者："Li, CZ (通讯作者)，Chongqing Med Univ, Chongqing Haifu Hosp, Coll Biomed Engn, Chongqing, Peoples R China."
来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA
关键词：Low-grade squamous intraepithelial lesion; high-risk human papillomavirus infection; treatment modality; age; education level; maternity history
摘要："Objective: To use logistic regression to analyze the attributes underlying patients' treatment options for low-grade squamous intraepithelial lesion (LSIL) complicated with high-risk human papillomavirus (HR-HPV) infection, and identify the best benefit group of different treatment options.Methods: Clinical data of 197 LSIL patients with HR-HPV infection between June 2009 and February 2022 were collected. According to the treatment options chosen by the patients, they were divided into the interferon, photodynamic therapy, follow-up observation, and focused ultrasound (FUS) treatment groups. One-way analysis of variance (ANOVA) and multivariate logistic regression analysis were used to analyze the influencing factors, including age, occupation, education level, maternity history, reason for encounter, route of consultation, annual personal and household income, screening for related risk factors, and identifying the best benefit group of different treatment options.Results: One-way ANOVA revealed a statistically significant difference in age, education level, maternity history, reason for encounter, and annual household income (p < 0.05). Multivariate logistic regression analysis was performed on these five factors, indicating that age & LE;35 years, high school educational level or higher, and no childbirth history were independent risk factors influencing patients' choices of FUS treatment. The receiver operating characteristic curve was used to determine the age threshold of 31 years.Conclusion: Age, educational level, and maternity history were independent risk factors influencing patients' choice of treatment modality for LSIL complicated with HR-HPV infection. Age & LE;31 years, high school, equivalent, or higher educational level, and no childbirth yielded a higher rate of choosing FUS treatment for LSIL patients with HR-HPV infection."