Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment

作者全名："Li, Junwu; Zheng, Jun; Zhang, Ronggui; Zhang, Weili; Zhang, Junyong; Zhang, Yuanfeng"

作者地址："[Li, Junwu; Zheng, Jun; Zhang, Ronggui; Zhang, Weili; Zhang, Junyong; Zhang, Yuanfeng] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China"

通信作者："Zhang, YF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:000932261400069

JCR分区：Q1

影响因子：4.6

年份：2022

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："To analyze the expression levels, prognostic value and immune infiltration association of Holliday junction protein (HJURP) as well as its feasibility as a pan-cancer biomarker for different cancers. The Protter online tool was utilized to obtain the localization of HJURP, then the methylation of HJURP in tumors were further explored. Thereafter, the mRNA data and clinical characteristics of 33 tumor types from TCGA database were obtained to investigate the expression and prognostic relationship of HJURP in different tumor types. Finally, the composition pattern and immune infiltration of HJURP in different tumors were detected in Tumor Immune Estimation Resource. HJURP was abnormally expressed in most of the cancer types and subtypes in TCGA database. Also, it was associated with poor prognosis of different cohorts. At the same time, the results also showed that HJURP was related to tumor immune evasion through different mechanisms, including T cell rejection and methylation in different cancer types. Besides, the methylation of HJURP was inversely proportional to mRNA expression levels, which mediated the dysfunctional phenotypes of T cells and poor prognosis of different cancer types. Alternatively, our results indicated that HJURP expression was associated with immune cell infiltration in a variety of cancers. HJURP may serve as an oncogenic molecule, and its expression and immune infiltration characteristics can be used as a biomarker for cancer detection, prognosis, treatment design and follow-up."

基金机构：Research Program of Natural Science Foundation in Chongqing [cstc2021jcyjmsxmX0484]; National Natural Science Foundation of China [81801507]; Kuanren Talent Program of Second Affiliated Hospital of Chongqing Medical University [KY2019Y004]

基金资助正文：This work was supported by the Research Program of Natural Science Foundation in Chongqing (cstc2021jcyjmsxmX0484); National Natural Science Foundation of China (No. 81801507); and Kuanren Talent Program of Second Affiliated Hospital of Chongqing Medical University (KY2019Y004).