Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease

作者全名："Guo, Tong-Tong; Zhang, Zheng; Sun, Yan; Zhu, Rui-Yang; Wang, Fei-Xia; Ma, Lian-Ju; Jiang, Lin; Liu, Han-Deng"

作者地址："[Guo, Tong-Tong; Wang, Fei-Xia; Ma, Lian-Ju; Jiang, Lin; Liu, Han-Deng] Chongqing Med Univ, Expt Teaching Ctr, Lab Tissue & Cell Biol, Chongqing 400016, Peoples R China; [Guo, Tong-Tong; Zhang, Zheng; Sun, Yan; Zhu, Rui-Yang; Wang, Fei-Xia; Liu, Han-Deng] Chongqing Med Univ, Dept Mol Med, Chongqing 400016, Peoples R China; [Guo, Tong-Tong; Zhang, Zheng; Sun, Yan; Zhu, Rui-Yang; Wang, Fei-Xia; Liu, Han-Deng] Chongqing Med Univ, Canc Res Ctr, Chongqing 400016, Peoples R China"

通信作者："Liu, HD (通讯作者)，Chongqing Med Univ, Expt Teaching Ctr, Lab Tissue & Cell Biol, Chongqing 400016, Peoples R China.; Liu, HD (通讯作者)，Chongqing Med Univ, Dept Mol Med, Chongqing 400016, Peoples R China.; Liu, HD (通讯作者)，Chongqing Med Univ, Canc Res Ctr, Chongqing 400016, Peoples R China."

来源：NUTRIENTS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000940026500001

JCR分区：Q1

影响因子：5.9

年份：2023

卷号：15

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：sodium butyrate; microbiome-gut-brain axis; neuroinflammation; gut microbial dysbiosis; Parkinson's disease

摘要："Parkinson's disease (PD) is a prevalent type of neurodegenerative disease. There is mounting evidence that the gut microbiota is involved in the pathogenesis of PD. Sodium butyrate (NaB) can regulate gut microbiota and improve brain functioning in neurological disorders. Hence, we examined whether the neuroprotective function of NaB on PD was mediated by the modulation of gut microbial dysbiosis and revealed its possible mechanisms. Mice were administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 7 consecutive days to construct the PD model. NaB gavage was given 2 h after the daily MPTP injections for 21 days. NaB improved the motor functioning of PD mice, increased striatal neurotransmitter levels, and reduced the death of dopaminergic neurons. The 16S rRNA sequencing analysis revealed that NaB restored the gut microbial dysbiosis. NaB also attenuated the intestinal barrier's disruption and reduced serum, colon, and striatal pro-inflammatory cytokines, along with inhibiting the overactivation of glial cells, suggesting an inhibitory effect on inflammation from NaB throughout the gut-brain axis of the PD mice. Mechanistic studies revealed that NaB treatment suppressed the TLR4/MyD88/NF-kB pathway in the colon and striatum. In summary, NaB had a neuroprotective impact on the PD mice, likely linked to its regulation of gut microbiota to inhibit gut-brain axis inflammation."

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