Molecular subtypes predict the preferential site of distant metastasis in advanced breast cancer: a nationwide retrospective study

作者全名："Fan, Jin-Hu; Zhang, Su; Yang, Huan; Yi, Zong-Bi; Ouyang, Qu-Chang; Yan, Min; Wang, Xiao-Jia; Hu, Xi-Chun; Jiang, Ze-Fei; Huang, Tao; Tong, Zhong-Sheng; Wang, Shu-Sen; Yin, Yong-Mei; Li, Hui; Yang, Run-Xiang; Yang, Hua-Wei; Teng, Yue-E.; Sun, Tao; Cai, Li; Li, Hong-Yuan; Ouyang, Xue-Nong; He, Jian-Jun; Liu, Xin-Lan; Yang, Shun-E.; Wang, Jia-Yu; Xu, Bing-He; Qiao, You-Lin"

作者地址："[Fan, Jin-Hu; Yang, Huan; Qiao, You-Lin] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Dept Canc Epidemiol, Natl Canc Ctr,Natl Clin Res Ctr Canc, Beijing, Peoples R China; [Zhang, Su] Dalian Med Univ, Dept Operat Management, Affiliated Hosp 1, Dalian, Peoples R China; [Yi, Zong-Bi; Wang, Jia-Yu; Xu, Bing-He] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Dept Med Oncol, Natl Canc Ctr,Natl Clin Res Ctr Canc, Beijing, Peoples R China; [Ouyang, Qu-Chang] Hunan Canc Hosp, Dept Breast Canc Med Oncol, Changsha, Peoples R China; [Yan, Min] Zhengzhou Univ, Henan Breast Canc Ctr, Dept Breast Dis, Affiliated Canc Hosp, Zhengzhou, Peoples R China; [Yan, Min] Henan Canc Hosp, Zhengzhou, Peoples R China; [Wang, Xiao-Jia] Zhejiang Canc Hosp, Dept Med Oncol, Hangzhou, Peoples R China; [Hu, Xi-Chun] Fudan Univ, Dept Med Oncol, Shanghai Canc Ctr, Shanghai, Peoples R China; [Jiang, Ze-Fei] Chinese Peoples Liberat Army PLA Gen Hosp, Dept Breast Canc, Med Ctr 5, Beijing, Peoples R China; [Huang, Tao] Ningxia Med Univ, Dept oncol, Gen Hosp, Dept Breast & Thyroid Surg, Yinchuan, Ningxia, Peoples R China; [Tong, Zhong-Sheng] Xinjiang Med Univ, Dept Breast Canc & Lymphoma, Affiliated Tumor Hosp, Dept Breast Oncol, Urumqi, Peoples R China; [Wang, Shu-Sen] Sun Yat Sen Univ, Dept Med Oncol, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Peoples R China; [Yin, Yong-Mei] Nanjing Med Univ, Dept Med Oncol, Affiliated Hosp 1, Nanjing, Peoples R China; [Li, Hui] Sichuan Prov Tumor Hosp, Dept Breast Surg, Chengdu, Sichuan, Peoples R China; [Yang, Run-Xiang] Kunming Med Univ, Yunnan Canc Hosp, Dept Med Oncol, Kunming, Peoples R China; [Yang, Hua-Wei] Guangxi Med Univ, Dept Breast Surg, Affiliated Tumor Hosp, Nanning, Peoples R China; [Teng, Yue-E.] China Med Univ, Dept Med Oncol, Hosp 1, Shenyang, Peoples R China; [Teng, Yue-E.] China Med Univ, Dept Thorac Surg, Hosp 1, Shenyang, Peoples R China; [Sun, Tao] China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Med Oncol,Liaoning Breast Canc Res, Shenyang, Peoples R China; [Cai, Li] Harbin Med Univ, Dept Internal Med Oncol 4, Canc Hosp, Harbin, Peoples R China; [Li, Hong-Yuan] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, Chongqing, Peoples R China; [Ouyang, Xue-Nong] 900Hosp Joint Logist Team, Dept Med Oncol, Fuzhou, Peoples R China; [He, Jian-Jun] Xi An Jiao Tong Univ, Dept Breast Surg, Affiliated Hosp 1, Xian, Peoples R China"

通信作者："Qiao, YL (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Dept Canc Epidemiol, Natl Canc Ctr,Natl Clin Res Ctr Canc, Beijing, Peoples R China.; Wang, JY; Xu, BH (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Dept Med Oncol, Natl Canc Ctr,Natl Clin Res Ctr Canc, Beijing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000940392000001

JCR分区：Q2

影响因子：4.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：advanced breast cancer; molecular subtype; site of distant metastasis; retrospective study; clinical epidemiological characteristic

摘要："ObjectiveThis study aimed to explore possible associations between molecular subtypes and site of distant metastasis in advanced breast cancer (ABC). Methods3577 ABC patients were selected from 21 hospitals of seven geographic regions in China from 2012-2014. A questionnaire was designed to collect medical information regarding demographic characteristics, risk factors, molecular subtype, recurrence/metastasis information, and disease-free survival (DFS). The cancers were classified into Luminal A, Luminal B, HER2-enriched and Triple Negative subtypes. Chi-square test and multivariate Cox proportional hazard models were performed to explore the associations between molecular subtypes and distant metastasis sites. ResultsA total of 2393 cases with molecular subtypes information were finally examined. Patients with Luminal A (51.1%) and Luminal B (44.7%) were most prone to bone metastasis, whereas liver metastasis was more frequently observed in HER2-enriched ABC patients (29.1%).The cumulative recurrence and metastasis rates of ABC patients at 36 months of DFS were the most significant within molecular types, of which Triple Negative was the highest (82.7%), while that of Luminal A was the lowest (58.4%). In the adjusted Cox regression analysis, Luminal B, HER2-enriched and Triple Negative subtypes increased the risk of visceral metastasis by 23%, 46% and 87% respectively. In addition, Triple Negative patients had a higher probability of brain metastasis (HR 3.07, 95% CI: 1.04-9.07). ConclusionMolecular subtypes can predict the preferential sites of distant metastasis, emphasizing that these associations were of great help in choices for surveillance, developing appropriate screening and cancer management strategies for follow-up and personalized therapy in ABC patients."

基金机构："Investigator initiated program of National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College [CH-BC-045]"

基金资助正文："This work was supported by the Investigator initiated program of National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CH-BC-045)."