Dysgranular retrosplenial cortex modulates histaminergic and nonhistaminergic itch processing

作者全名："Long, Jun-hui; Wang, Pu-jun; Li, Zhi-fang; Yao, Juan; Li, Xuan; Sui, Jian-feng; Liao, Jun; Wang, Ping; Li, Xiao-feng; Liu, Shu-lei"

作者地址："[Long, Jun-hui; Wang, Pu-jun; Liao, Jun; Wang, Ping; Liu, Shu-lei] 958th Army Hosp Chinese Peoples Liberat Army, Dept Dermatol, Chongqing, Peoples R China; [Yao, Juan; Li, Xuan; Sui, Jian-feng] Army Med Univ, Coll Basic Med Sci, Expt Ctr Basic Med, Chongqing 400038, Peoples R China; [Li, Zhi-fang] Army Med Univ, Coll Basic Med Sci, Dept Foreign Languages, Chongqing 400038, Peoples R China; [Li, Xiao-feng] Chongqing Med Univ, Affiliated Hosp 3, Dept Radiol, Chongqing 401120, Peoples R China"

通信作者："Liu, SL (通讯作者)，958th Army Hosp Chinese Peoples Liberat Army, Dept Dermatol, Chongqing, Peoples R China.; Li, XF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Radiol, Chongqing 401120, Peoples R China."

来源：BEHAVIOURAL BRAIN RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000942958700001

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：443

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Itch; Pharmacogenetic inhibition; Retrosplenial cortex; Anterior cingulate cortex; Rats

摘要："Itch is an unpleasant sensation followed by an intense desire to scratch. Previous researches have advanced our understanding about the role of anterior cingulate cortex and prelimbic cortex in itch modulation, whereas little is known about the effects of retrosplenial cortex (RSC) during this process. Here we firstly confirmed that the neuronal activity of dysgranular RSC (RSCd) is significantly elevated during itch-scratching processing through cFos immunohistochemistry and fiber photometry recording. Then with designer receptors exclusively activated by designer drugs approaches, we found that pharmacogenetic inhibition of global RSCd neurons attenuated the number of scratching bouts as well as the cumulative duration of scratching bouts elicited by both 5-HT or compound 48/80 injection into rats' nape or cheek; selective inhibition of the pyramidal neurons in RSCd, or of the excitatory projections from caudal anterior cingulate cortex (cACC) to RSCd, demonstrated the similar effects of decreasing itch-related scratching induced by both 5-HT or compound 48/80. Pharmacogenetic intervention of the neuronal or circuitry activities did not affect rats' motor ability. This study presents direct evidence that pyramidal neurons in RSCd, and the excitatory projection from cACC to RSCd are critically involved in central regulation of both histaminergic and nonhistaminergic itch."

基金机构：Key Program for the Talents by Army Medical University; National Natural Science Foundation of China [2023ZDXM001]; Chongqing Health Commission [2023ZDXM001]; Science and Technology Bureau; [82271542]

基金资助正文："This work was supported by the Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2023ZDXM001, to S. -l. Liu) ; Key Program for the Talents by Army Medical University (2019, to S. -l. Liu) ; National Natural Science Foundation of China (No. 82271542 to J. -F. Sui) ."