"Association Between Visceral Fat, Blood Pressure and Arterial Stiffness in Patients with HFpEF: A Mediation Analysis"

作者全名："Sun, Min; Gao, Lei; Bai, Hongmei; Hu, Weiwei; Zhang, Xiaofang; Xiao, Jin; Deng, Xiangliang; Tao, Hongmei; Ge, Ping; Qin, Yuhong; Zhang, Dongying"

作者地址："[Sun, Min; Gao, Lei; Bai, Hongmei; Hu, Weiwei; Zhang, Xiaofang; Xiao, Jin; Deng, Xiangliang; Tao, Hongmei; Qin, Yuhong; Zhang, Dongying] Chongqing Med Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Sun, Min; Ge, Ping] Chongqing Med Univ, Hlth Management Ctr, Branch 1, Affiliated Hosp, Chongqing, Peoples R China"

通信作者："Qin, YH; Zhang, DY (通讯作者)，Chongqing Med Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：DIABETES METABOLIC SYNDROME AND OBESITY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000948545900001

JCR分区：　

影响因子：　

年份：2023

卷号：16

期号：　

开始页：653

结束页：662

文献类型：Article

关键词：mediation analysis; blood pressure; visceral fat area; brachial-ankle pulse wave velocity; HFpEF

摘要："Purpose: To investigate the association of visceral fat with arterial stiffness of heart failure patients with preserved ejection fraction (HFpEF) and to evaluate the extent to which this association is mediated by blood pressure (BP).Patients and Methods: This cross-sectional descriptive study (clinicaltrials.gov identifier: NCT04535726) recruited 94 patients with HFpEF totally from October to December 2020. The obesity-related measurements included visceral fat area (VFA), body mass index and fat percentage. Brachial-ankle pulse wave velocity (baPWV) was used to estimate the degree of arterial stiffness. Mediation analysis was performed to reveal whether the effect of visceral fat area on arterial stiffness can be mediated by BP in patients with HFpEF and the extent to which this association was mediated by BP.Results: About 93.6% of HFpEF patients were accompanied with abdominal obesity. Patients in baPWV >1800cm/s group were older, with a higher incidence of type 2 diabetes mellitus (T2DM), hypertension and abdominal obesity. VFA, systolic BP (SBP), diastolic BP (DBP) and pulse pressure (PP) were correlated with baPWV in total group. Adjusted for age >75 years old, gender, smoking, T2DM, calcium channel blocker and statins, the mediation effect of systolic SBP and PP on the VFA-baPWV association were 53.3% (indirect effect was 2.28, 95% CI 0.62-4.73) and 48.4% (indirect effect was 2.07, 95% CI 0.51-4.38), respectively. DBP failed to mediate the association between VFA and baPWV (indirect effect was 0.50, 95% CI -0.41-2.14).Conclusion: The association of visceral fat with baPWV in HFpEF patients may be partly accounted for SBP or PP. Elevated SBP and PP might be important potential targets for preventing arterial stiffness in HFpEF patients."

基金机构：National Natural Science Foundation of China [81970203]; Chongqing Health Commission [2022MSXM028]; China Cardiovascular Health Alliance -Access Research Fund [2021-CCA-ACCESS-130]

基金资助正文："Funding This work was supported by the National Natural Science Foundation of China (number 81970203, 81970203) ; Chongqing Health Commission (number 2022MSXM028) ; China Cardiovascular Health Alliance -Access Research Fund (number 2021-CCA-ACCESS-130) ."