The versatile roles of testrapanins in cancer from intracellular signaling to cell-cell communication: cell membrane proteins without ligands

作者全名："Zhou, Zhihang; Yang, Zihan; Zhou, Li; Yang, Mengsu; He, Song"

作者地址："[Zhou, Zhihang; Zhou, Li; He, Song] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhou, Zhihang; Yang, Zihan; Zhou, Li; Yang, Mengsu] City Univ Hong Kong, Dept Biomed Sci, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China; [Zhou, Zhihang; Yang, Zihan; Zhou, Li; Yang, Mengsu] City Univ Hong Kong, Tung Biomed Sci Ctr, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China; [Yang, Zihan; Yang, Mengsu] City Univ Hong Kong, Dept Precis Diagnost & Therapeut Technol, Futian Res Inst, Shenzhen, Guangdong, Peoples R China"

通信作者："Zhou, ZH; He, S (通讯作者)，Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Chongqing, Peoples R China.; Zhou, ZH (通讯作者)，City Univ Hong Kong, Dept Biomed Sci, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China."

来源：CELL AND BIOSCIENCE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000950733300002

JCR分区：Q1

影响因子：7.5

年份：2023

卷号：13

期号：1

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结束页：　

文献类型：Review

关键词：Tetraspanin; Cancer; Metastasis; Extracellular vesicles; Immunonology

摘要："The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in mammals. They are variably expressed on the cell surface, various intracellular organelles and vesicles in nearly all cell types. Different from the majority of cell membrane proteins, TSPANs do not have natural ligands. TSPANs typically organize laterally with other membrane proteins to form tetraspanin-enriched microdomains (TEMs) to influence cell adhesion, migration, invasion, survival and induce downstream signaling. Emerging evidence shows that TSPANs can regulate not only cancer cell growth, metastasis, stemness, drug resistance, but also biogenesis of extracellular vesicles (exosomes and migrasomes), and immunomicroenvironment. This review summarizes recent studies that have shown the versatile function of TSPANs in cancer development and progression, or the molecular mechanism of TSPANs. These findings support the potential of TSPANs as novel therapeutic targets against cancer."

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