Altered neurometabolite levels in the brains of patients with depression: A systematic analysis of magnetic resonance spectroscopy studies

作者全名："Xie, Xiongfei; Shi, Yan; Ma, Lin; Yang, Wenqin; Pu, Juncai; Shen, Yiqing; Liu, Yiyun; Zhang, Hanping; Lv, Fajin; Hu, Liangbo"

作者地址："[Xie, Xiongfei; Shi, Yan; Ma, Lin; Yang, Wenqin; Hu, Liangbo] Chongqing Med Univ, Yongchuan Hosp, Dept Radiol, Chongqing, Peoples R China; [Pu, Juncai; Shen, Yiqing; Zhang, Hanping] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Pu, Juncai; Shen, Yiqing; Liu, Yiyun; Zhang, Hanping] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China; [Lv, Fajin] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China"

通信作者："Hu, LB (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Dept Radiol, Chongqing, Peoples R China.; Lv, FJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000951460000001

JCR分区：Q1

影响因子：6.6

年份：2023

卷号：328

期号：　

开始页：95

结束页：102

文献类型：Article

关键词：Metabolite; Magnetic resonance spectroscopy; Depression; Brain

摘要："Background: Numerous magnetic resonance spectroscopy (MRS) studies have reported metabolic abnormalities in the brains of patients with depression, although inconsistent results have been reported. The aim of this study was to explore changes in neurometabolite levels in patients with depression across large-scale MRS studies. Method: A total of 307 differential metabolite entries associated with depression were retrieved from 180 MRS studies retrieved from the Metabolite Network of Depression Database. The vote-counting method was used to identify consistently altered metabolites in the whole brain and specific brain regions of patients with depression. Results: Only few differential neurometabolites showed a stable change trend. The levels of total choline (tCho) and the tCho/N-acetyl aspartate (NAA) ratio were consistently higher in the brains of patients with depression, and that the levels of NAA, glutamate and glutamine (Glx), and gamma-aminobutyric acid (GABA) were lower. For specific brain regions, we found lower Glx levels in the prefrontal cortex and lower GABA concentrations in the occipital cortex. We also found lower concentrations of NAA in the anterior cingulate cortex and prefrontal cortex. The levels of tCho were higher in the prefrontal cortex and putamen. Conclusion: Our results revealed that most altered neurometabolites in previous studies lack of adequate reproducibility. Through vote-counting method with large-scale studies, downregulation of glutamatergic neu-rometabolites, impaired neuronal integrity, and disturbed membrane metabolism were found in the pathobiology of depression, which contribute to existing knowledge of neurometabolic changes in depression. Further studies based on a larger dataset are needed to confirm our findings."

基金机构："Key Project of Medical Research Program of Chongqing Health and Family Planning Commission [2017ZDXM020]; Natural Science Foundation Project of China [82101596]; Young Elite Scientists Sponsorship Program by CAST [2021QNRC001]; China Postdoctoral Science Foundation [2021MD703926, 2021TQ0396, 2021MD703928]"

基金资助正文："This work was supported by the Key Project of Medical Research Program of Chongqing Health and Family Planning Commission (2017ZDXM020) , the Natural Science Foundation Project of China (82101596) , the Young Elite Scientists Sponsorship Program by CAST (2021QNRC001) , and the China Postdoctoral Science Foundation (2021MD703926, 2021TQ0396, 2021MD703928) . The funding source had no role in the study design, data analysis, interpretation of results, or decision to publish."