Ultrasound-responsive smart composite biomaterials in tissue repair
作者全名："Han, Xiaoyu; Yi, Weiwei; Chen, Shuyu; Cai, Zhengwei; Zhu, Ying; Han, Wang; Guo, Xiya; Shen, Jieliang; Cui, Wenguo; Bai, Dingqun"
作者地址："[Han, Xiaoyu; Yi, Weiwei; Chen, Shuyu; Zhu, Ying; Han, Wang; Guo, Xiya; Shen, Jieliang; Bai, Dingqun] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China; [Cai, Zhengwei; Cui, Wenguo] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Shanghai Key Lab Prevent & Treatme, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China"
通信作者："Shen, JL; Bai, DQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Shanghai Key Lab Prevent & Treatme, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."
来源：NANO TODAY
ESI学科分类：PHYSICS
WOS号：WOS:000953799900001
JCR分区：Q1
影响因子：17.4
年份：2023
卷号：49
期号：
开始页：
结束页：
文献类型：Review
关键词：Ultrasound; Smart composite biomaterials; Tissue Repair; Remote control; Trigger
摘要："Tissue repair is a cascade of sequential biological events initiated to repair damages inflicted by trauma, pathogenic bacteria, or other injury-causing factors, with the aim of restoring tissue integrity. Smart composite biomaterials are able to react to biological signals released after tissue damages and make ad-justments that suit the dynamic and complex internal environment based on external information, thus maintaining the homeostasis of the internal environment in the human body. Ultrasound is considered as an excellent ""remote control"" and ""trigger"" for smart composite biomaterials due to its basic technical characteristic effects that primarily include cavitation, microstreaming, scattering, and acoustic radiation force. Here, we presented the first comprehensive and systematic review of the research progress of ul-trasound-responsive smart composite biomaterials in tissue repair. In this review, firstly, we elaborated on the definition and mechanism of ultrasound, followed by a brief analysis of the principles of the response of biomaterials to ultrasound. Then, to systematically review the subject, we divide ultrasound-responsive smart composite biomaterials into following categories: anti-infective, skin repair, osteogenic, gene transfection, thrombolytic, neuromuscular, and imaging. Finally, there is a brief summary of ultrasound -responsive smart composite biomaterials, and an outlook based on characteristics of physiological repair of tissues in each system.(c) 2023 Elsevier Ltd. All rights reserved."
基金机构："National Key Research and Development Program of China [2020YFA0908200, 2020YFC2005900]; National Natural Science Foundation of China [82172533, 82002402, 32101104]; National Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0792]; Chongqing Municipal Education Commission, Innovative Research Group of Universities in Chongqing [CXQT21018]; State Key Laboratory of Ultrasound Engineering in Medicine and Engineering [2020KFA3019]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0076]"
基金资助正文："This work was supported in part by the National Key Research and Development Program of China (2020YFA0908200, 2020YFC2005900) , National Natural Science Foundation of China (82172533, 82002402 and 32101104) , The National Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0792) , Chongqing Municipal Education Commission, Innovative Research Group of Universities in Chongqing (CXQT21018) , State Key Laboratory of Ultrasound Engineering in Medicine and Engineering (2020KFA3019), Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0076)."
