"Co-infection of hepatitis E virus, Clonorchis sinensis, and Escherichia coli: A case report"

作者全名："Zhang, Lu; Wang, Xiaohao; Zhang, Jing; Wang, Zhongrong; Cai, Dachuan"

作者地址："[Zhang, Lu; Wang, Xiaohao; Cai, Dachuan] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing, Peoples R China; [Zhang, Jing] Chongqing Med Univ, Basic Coll Med, Dept Pathogen Biol, Chongqing, Peoples R China; [Wang, Zhongrong] Tongliang Dist Peoples Hosp, Dept Gastroenterol, Chongqing, Peoples R China"

通信作者："Cai, DC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing, Peoples R China.; Wang, ZR (通讯作者)，Tongliang Dist Peoples Hosp, Dept Gastroenterol, Chongqing, Peoples R China."

来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000953805300001

JCR分区：Q2

影响因子：5.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：hepatitis E virus; HEV; Clonorchis sinensis; co-infection; Escherichia coli

摘要："Hepatitis E virus (HEV) is a common cause of acute hepatitis that threatens human health worldwide. With the popularization of detection technology, the reports of hepatitis E have gradually increased. Here, we present a rare case of co-infection with hepatitis E viruses, Clonorchis sinensis and Escherichia coli. A 52-year-old man was hospitalized because of fatigue, jaundice, and nausea for more than 2 weeks. Laboratory tests showed elevated bilirubin, aminotransferase (ALT), and aspartate aminotransferase (AST); HEV-IgM was positive, and HEV-RNA could be detected. Moreover, parasites were found in the biliary drainage and the biliary culture, which suggested Escherichia coli. The patient was effectively treated with praziquantel, imipenem, and hepatoprotective drugs and his clinical symptoms were relieved after 2 months; total bilirubin decreased to 85.1 mu mol/L, ALT decreased to 92.4 U/L, and AST decreased to 102 U/L."

基金机构："First batch of key Disciplines On Public Health in Chongqing, Health Commission of Chongqing, China"

基金资助正文："This work was supported by The First batch of key Disciplines On Public Health in Chongqing, Health Commission of Chongqing, China."