Mito-battery: Micro-nanohydrogel microspheres for targeted regulation of cellular mitochondrial respiratory chain

作者全名："Wang, Xingkuan; Lei, Yiting; Jiang, Ke; Yan, Caiping; Shen, Jieliang; Zhao, Weikang; Xiang, Chao; Cai, Zhengwei; Song, Yang; Chen, Lu; Cui, Wenguo; Li, Yuling"

作者地址："[Wang, Xingkuan; Jiang, Ke; Yan, Caiping; Xiang, Chao; Chen, Lu; Li, Yuling] Affiliated Hosp, North Sichuan Med Coll, Lab Biol Tissue Engn & Digital Med, 1 South Maoyuan Rd, Nanchong 637000, Sichuan, Peoples R China; [Wang, Xingkuan; Cai, Zhengwei; Cui, Wenguo] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Sch Med.Shanghai Key Lab Prevent & Treatment Bone, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China; [Lei, Yiting; Shen, Jieliang; Zhao, Weikang] Chongqing Med Univ, Affiliated Hosp 1, Orthoped Lab, Dept Orthoped, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Song, Yang] Chongqing Univ, Bioengn Coll, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400030, Peoples R China"

通信作者："Chen, L; Li, YL (通讯作者)，Affiliated Hosp, North Sichuan Med Coll, Lab Biol Tissue Engn & Digital Med, 1 South Maoyuan Rd, Nanchong 637000, Sichuan, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Sch Med.Shanghai Key Lab Prevent & Treatment Bone, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."

来源：NANO TODAY

ESI学科分类：PHYSICS

WOS号：WOS:000956036400001

JCR分区：Q1

影响因子：17.4

年份：2023

卷号：49

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Mitochondrial respiratory chain; Hydrogel microsphere; Microfluidics; Injectable; Osteoarthritis

摘要："The mitochondrial respiratory chain (MRC) plays an essential role in regulating cellular energy metabolism and oxidative stress. Repairing damaged MRC function can efficiently provide cells with energy to fight inflammation. Herein, with the inspiration by a rechargeable battery, microfluidics was used to prepare hyaluronic acid hydrogel microspheres as shells and con-covalently connected the inner core-SS-31 peptide and Wyrgrl peptide co-modified long-circulating liposomes loaded with resveratrol (REV) to the nano -network of microspheres to construct a ""Mito-Battery"" that could promote cell energy production and fight inflammation by targeted regulation of MRC functions. Modification of peptide could increase its cellular uptake and enhance the mitochondrial-targeting of ""Mito-Battery."" Meanwhile, REV loaded in the lipo-somes can activate SIRT3 protein and synergistically enhance the MRC electron transfer efficiency with SS -31. ""Mito-Battery"" effectively delayed the progression of the disease in a rat bone and joint model. Thus, ""Mito-Battery"" has great potential in the treatment of degenerative diseases related to MRC dysfunction.(c) 2023 Elsevier Ltd. All rights reserved."

基金机构："National Key Research and Development Program of China [2020YFA0908200]; National Science Foundation of China [82102578, 82102571, 52273133]; Shanghai Municipal Health and Family Planning Commission [2022XD055]; Applied Basic Research Programs of the Science and Technology Department of Sichuan Province [2021YJ0467]; China Postdoctoral Science Foundation [2022M720603]; North Sichuan Medical College [csts2019jcyj-bsh0068]; Chongqing postdoctoral Science Foundation [2021ZK001]; Research Project of the Affiliated Hospital of North Sichuan Medical College; [CBY20-QA-Z04]"

基金资助正文："X. Wang, Y. Lei, K. Jiang contributed equally to this work. This work is supported by the National Key Research and Development Program of China (2020YFA0908200) , National Science Foundation of China (82102578, 82102571 and 52273133) , Shanghai Municipal Health and Family Planning Commission (2022XD055) , Applied Basic Research Programs of the Science and Technology Department of Sichuan Province (2021YJ0467) , China Postdoctoral Science Foundation (2022M720603) , Research Project of the Affiliated Hospital of North Sichuan Medical College (2021ZK001) , and the Research Project of the North Sichuan Medical College (CBY20-QA-Z04) , and Chongqing postdoctoral Science Foundation (csts2019jcyj-bsh0068) ."