"Current Pubertal Development in Chinese Children and the Impact of Overnutrition, Lifestyle, and Perinatal Factors"

作者全名："Liang, Xinyi; Huang, Ke; Dong, Guangping; Chen, Ruimin; Chen, Shaoke; Zheng, Rongxiu; Wang, Chunlin; Wei, Haiyan; Cao, Bingyan; Liang, Yan; Yao, Hui; Su, Zhe; Maimaiti, Mireguli; Luo, Feihong; Li, Pin; Zhu, Min; Du, Hongwei; Yang, Yu; Cui, Lanwei; Si, Shuting; Bai, Guannan; Yu, Yunxian; Wang, Er-Gang; Hofman, Paul L.; Fu, Junfen"

作者地址："[Liang, Xinyi; Huang, Ke; Dong, Guangping; Bai, Guannan; Fu, Junfen] Zhejiang Univ, Natl Clin Res Ctr Child Hlth, Dept Endocrinol, Childrens Hosp,Sch Med, Hangzhou 310057, Peoples R China; [Chen, Ruimin] Childrens Hosp Fuzhou, Dept Endocrinol, Fuzhou 350001, Fujian Province, Peoples R China; [Chen, Shaoke] Maternal & Child Hlth Hosp Guangxi Zhuang Autonomo, Dept Pediat, Nanning 530002, Peoples R China; [Zheng, Rongxiu] Tianjin Med Univ, Dept Pediat, Cent Hosp, Tianjin 300204, Peoples R China; [Wang, Chunlin] Zhejiang Univ, Dept Pediat, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Peoples R China; [Wei, Haiyan] Zhengzhou Childrens Hosp, Dept Endocrinol, Zhengzhou 450012, Peoples R China; [Cao, Bingyan] Capital Med Univ, Beijing Childrens Hosp, Natl Med Ctr Childrens Hlth, Dept Endocrinol, Beijing 100045, Peoples R China; [Liang, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan 430030, Peoples R China; [Yao, Hui] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Pediat, Wuhan 430019, Peoples R China; [Su, Zhe] Shenzhen Childrens Hosp, Dept Endocrinol, Shenzhen 518034, Peoples R China; [Maimaiti, Mireguli] Xinjiang Med Univ, Dept Pediat, Affiliated Hosp 1, Urumqi 839911, Peoples R China; [Luo, Feihong] Fudan Univ, Dept Pediat Endocrinol & Inherited Metab Dis, Childrens Hosp, Shanghai 200433, Peoples R China; [Li, Pin] Shanghai Jiao Tong Univ, Dept Endocrinol, Childrens Hosp, Shanghai 200240, Peoples R China; [Zhu, Min] Chongqing Med Univ, Dept Endocrinol, Childrens Hosp, Chongqing 400015, Peoples R China; [Du, Hongwei] Jilin Univ, Dept Pediat Endocrinol, Bethune Hosp 1, Changchun 130021, Peoples R China; [Yang, Yu] Jiangxi Prov Childrens Hosp, Dept Endocrinol, Nanchang 330006, Peoples R China; [Cui, Lanwei] Harbin Med Univ, Dept Pediat, Affiliated Hosp 1, Harbin 150010, Peoples R China; [Si, Shuting; Yu, Yunxian] Zhejiang Univ, Sch Publ Hlth, Sch Med, Dept Epidemiol & Hlth Stat, Hangzhou 310030, Peoples R China; [Wang, Er-Gang] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA; [Hofman, Paul L.] Univ Auckland, Liggins Inst, Auckland 1142, New Zealand; [Fu, Junfen] Zhejiang Univ, Natl Clin Res Ctr Child Hlth, Dept Endocrinol, Childrens Hosp,Sch Med, 3333 Binsheng Rd, Hangzhou 310052, Peoples R China; [Hofman, Paul L.] Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand"

通信作者："Fu, JF (通讯作者)，Zhejiang Univ, Natl Clin Res Ctr Child Hlth, Dept Endocrinol, Childrens Hosp,Sch Med, 3333 Binsheng Rd, Hangzhou 310052, Peoples R China.; Hofman, PL (通讯作者)，Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand."

来源：JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000956733900001

JCR分区：Q1

影响因子：5.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：onset of puberty; sexual maturation; breast development; precocious puberty; menarche; testicular volume

摘要："Context Age of pubertal onset has been decreasing in many countries but there have been no data on pubertal development in Chinese children over the last decade. Objective The primary objective of the study was to evaluate the current status of sexual maturation in Chinese children and adolescents. Secondary objectives were to examine socioeconomic, lifestyle, and auxological associations with pubertal onset. Methods In this national, cross-sectional, community-based health survey, a multistage, stratified cluster random sampling method was used to select a nationally representative sample, consisting of 231 575 children and adolescents (123 232 boys and 108 343 girls) between 2017 and 2019. Growth parameters and pubertal staging were assessed by physical examination. Results Compared to 10 years previously, the median age of Tanner 2 breast development and menarche were similar at 9.65 years and 12.39 years respectively. However, male puberty occurred earlier with a median age of testicular volume >= 4 mL of 10.65 years. Pubertal onset did occur earlier at the extremes, with 3.3% of the girls with breast development at 6.5-6.99 years old, increasing to 5.8% by 7.5-7.99 years old. Early pubertal onset was also noted in boys, with a testicular volume >= 4 mL noted in 1.5% at 7.5-7.99 years, increasing to 3.5% at 8.5-8.99 years old. Obesity and overweight increased risk of developing earlier puberty relative to normal weight in both boys and girls. Conclusion Over the past decade, pubertal development is occurring earlier in Chinese children. While the cause is multifactorial, overweight and obesity are associated with earlier puberty onset. The currently used normative pubertal data of precocious puberty may not be applicable to diagnose precocious puberty."

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