"The Global, Regional, and National Burden and Trends of NAFLD in 204 Countries and Territories: An Analysis From Global Burden of Disease 2019"

作者全名："Chen, Huilong; Zhan, Yuan; Zhang, Jinxiang; Cheng, Sheng; Zhou, Yuhao; Chen, Liyuan; Zeng, Zhilin"

作者地址："[Chen, Huilong; Zeng, Zhilin] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept & Inst Infect Dis, Wuhan, Peoples R China; [Zhan, Yuan; Zhou, Yuhao] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Natl Clin Res Ctr Resp Dis,Dept Resp & Crit Care M, Wuhan, Peoples R China; [Zhang, Jinxiang] Guangdong Med Univ, Hosp 2, Dept Spine Surg, Zhanjiang, Peoples R China; [Cheng, Sheng] Chongqing Med Univ, Univ Town Hosp, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Chen, Liyuan] Wuhan 1 Hosp, Dept Obstet & Gynecol, Wuhan, Peoples R China; [Zeng, Zhilin] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept & Inst Infect Dis, 1095 Jiefang Rd, Wuhan 430030, Peoples R China"

通信作者："Zeng, ZL (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept & Inst Infect Dis, 1095 Jiefang Rd, Wuhan 430030, Peoples R China."

来源：JMIR PUBLIC HEALTH AND SURVEILLANCE

ESI学科分类：　

WOS号：WOS:000957773600009

JCR分区：Q1

影响因子：8.5

年份：2022

卷号：8

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：non-alcoholic fatty liver disease; Global Burden of Disease Study 2019; epidemiologic change; diabetes mellitus type 2; stroke; ischemic heart disease; incidence; prevalence; mortality; disability-adjusted life-years

摘要："Background: Nonalcoholic fatty liver disease (NAFLD) poses a substantial socioeconomic burden and is becoming the fastest growing driver of chronic liver disease, potentially accompanied by a poor prognosis. Objective: We aim to elucidate the global and regional epidemiologic changes in NAFLD during the past 30 years and explore the interconnected diseases. Methods: Data on NAFLD incidence, prevalence, death, and disability-adjusted life-years (DALYs) were extracted from the Global Burden of Disease Study 2019. The age-standardized incident rate (ASIR), age-standardized prevalent rate (ASPR), age-standardized death rate (ASDR), and age-standardized DALYs were calculated to eliminate the confounding effects of age when comparing the epidemiologic changes between different geographical regions. In addition, we also investigated the correlation between the NAFLD burden and the sociodemographic index (SDI). Finally, the associations of the 3 common comorbidities with NAFLD were determined. Results: Globally, the incidence and prevalence of NAFLD both increased drastically during the past 3 decades (incidence: from 88,180 in 1990 to 172,330 in 2019, prevalence: from 561,370,000 in 1990 to 1,235,700,000 in 2019), mainly affecting young adults who were aged from 15 to 49 years. The ASIR increased slightly from 1.94 per 100,000 population in 1990 to 2.08 per 100,000 population in 2019, while ASPR increased from 12,070 per 100,000 population in 1990 to 15,020 per 100,000 population in 2019. In addition, the number of deaths and DALYs attributable to NAFLD increased significantly as well from 93,760 in 1990 to 168,970 in 2019 and from 2,711,270 in 1990 to 4,417,280 in 2019, respectively. However, the ASDR and age-standardized DALYs presented decreasing trends with values of estimated annual percentage change equaling to -0.67 and -0.82, respectively (ASDR: from 2.39 per 100,000 population in 1990 to 2.09 per 100,000 population in 2019; age-standardized DALYs: from 63.28 per 100,000 population in 1990 to 53.33 per 100,000 population in 2019). Thereinto, the burden of death and DALYs dominated the patients with NAFLD who are older than 50 years. Moreover, SDI appeared to have obvious negative associations with ASPR, ASDR, and age-standardized DALYs among 21 regions and 204 countries, although there is no marked association with ASIR. Finally, we found that the incidence and prevalence of NAFLD were positively related to those of diabetes mellitus type 2, stroke, and ischemic heart disease. Conclusions: NAFLD is leading to increasingly serious health challenges worldwide. The morbidity presented a clear shift toward the young populations, while the heavier burden of death and DALYs in NAFLD was observed in the aged populations and in regions with relatively low SDI. Comprehensive acquisition of the epidemiologic pattern for NAFLD and the identification of high-risk comorbidities may help policy makers and clinical physicians develop cost-effective prevention and control strategies, especially in countries with a high NAFLD burden."

基金机构："National Natural Science Foundation of China [81800041, 82000078]"

基金资助正文：Acknowledgments We are grateful to all the GBD 2019 staff for their contribution. This work was funded by the National Natural Science Foundation of China (grant numbers 81800041 and 82000078) .